71 results
Describe the relation between patterns in biomarkers of vascular inflammation, plaque instability and hypercoagulability and the incidence of recurrent ACS
Primary:2. To investigate the prevalence of vulnerable plaques, i.e. plaques with intraplaque hemorrhage on MRI, in individuals with type 2 diabetes, impaired and normal glucose tolerance and a minimal plaque thickness of 2mm on ultrasonography. To…
Primary Objective: 1. To determine whether there is a difference in arterial wall inflammation between well-controlled and poorly-controlled type 1 diabetes patients2. To determine whether patients with type 1 diabetes have a higher level of…
With this study we will evaluate the following hypothesis: Does acute systemic inflammation induces plaque instability and could it be repsonsible for the elevated risk of cardiovascular events. Eventually this study can contribute to the knowledge…
To answer the following research questions: 1. Do intimal arterial calcification and medial arterial calcification in the lower extremity arteries increase the occurrence of cardiovascular disease in people with a high risk of cardiovascular disease…
to identify novel molecular pathways resulting in premature atherosclerosis (PAS) in families where the traditional risk factors are not present / near absent.
In the current study, we want to determine and correlate the results of both perfusion capacity (with MR imaging) and sublingual glycocalyx dimensions in a) patients with proven obstructive coronary artery disease and b) patients with angina but…
The primary objectives of our study are:1. to compare the diagnostic performance of coronary CTA with coronary MRA to detect significant coronary stenoses (> 50% reduction in lumen diameter), in patients with a range of coronary calcium…
The aim of the study is to investigate the effect of statins on ery-apoB levels.
To evaluate anti-inflammatory effects of statin therapy on vessel wall inflammation by means of FDG PET/CT in AS patients.
To investigate the risk of deeath and incident (cardio)vascular disease in patients with a TIA or stroke aged 18-50 yearsTo investigate the riks of cognitive impairment and (vascular) dementia in patients with a TIA or stroke aged 18-50 yearsTo…
The overall objective of this project is to assess the interplay between classical risk factors (including lifestyle factors), plasma markers, markers of activated circulating cells and atherosclerosis burden at MR imaging (expressed as aortic…
To explore FDG-PET/CT to quantify the effect of CABG on inflammation in the arterial wall.
To assess the changes in cardiac function and the microcirculatory function in different thyroid states. We aim to identify how thyroid state affects changes in micro and macro hemodynamics.
Optimization of a recently developed 3T MRI protocol for imaging of the coronary and aortic vessel wall.
To determine the relationship between pericoronary adipose tissue (dys)function, in terms of the cytokine and adipokine secretion profile and histologic markers of inflammation, and coronary atherosclerosis.
The overall objective of this study is to assess to what extend different cognitive domains are affected by a recent TNA and which mechanism is responsible for this cognitive decline. We wanted to know whether the kind of TNA (focal, non-focal,…
The proposed project will have the following objectives:1. To investigate the correlation between 18F-FDG accumulation in plaques seen on PET-CT and plaque characteristics found with IVUS-VH and OCT.2. To investigate the correlation between…
The PRELHUDE study investigates the reversal of the ZAHARA3 study; whether subclinical congenital heart disease occurs in women who deliver prematurely for unknown reason. The biosamples taken during and after delivery will be used to determine…
The objective of the study comprises the identification of (tissue) biomarkers related to the risk of re-amputaion, systemic atehrosclerotic manifestations and woundhealing in patients with critical limb ischemia by investigating tissue biopts at…