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Is there a role for duplex ultrasound in patients with a clinical suspicion of temporal arteritis?

Determining the role of duplex ultrasound in patients with a clinical suspicion for temporal arteritis.Determing the sensitivity, specificity, negative predictive value and positive predictive value of duplex ultrasound in patients with a clinical…

Post-Approval Study of the GORE® VIABAHN® Endoprosthesis for Treatment of In-Stent Restenosis in the Superficial Femoral Artery.

To evaluate the post-market performance of the GORE® VIABAHN® Endoprosthesis for the treatment of in-stent restenosis in the superficial femoral artery.

Prevention of skeletal muscle and myocardial free-fatty acid induced microvascular dysfunction in skeletal muscle and myocardium by exercise

We hypothesize that the amount of physical activity correlates with insulin-induced microvascular recruitment during free-fatty acid infusion in skeletal muscle as well as in the heart. In this study we aim to test this hypothesis.

The diagnostic value of additional research in giant cell arteritis

This study aims to investigate the sensitivity and specificity of the history and physical examination for the diagnosis of giant cell arteritis, compared with the superficial temporal artery biopsy, and get more insight into the positive and…

The effects of red blood cell transfusion on the microcirculation in chronic anemic preterm neonates.

To determine the effect of a single red blood cell transfusion on the microcirculation.

Tackling underdiagnosis of Large Artery Giant Cell Arteritis: a prevalence and phenotype study.

The primary objectives of the study are to assess the prevalence of large artery inflammation in patients with temporal arteritis or an unexplained inflamatory response and the diagnostic utility of 18FDG-PET/CT in patients with an unexplained…

New Hoorn Study:
*Cause and consequences of disturbed microcirculation: effects of glucose tolerance status*

1. Do body fatness and/or body fat distribution show a linear association withmicrovascular function in normal as well as IGT subjects?2. Is the effect of body composition on the microvasculature mediated by alteredadipokine profile, low-grade…

Protocol for study comparing skin autofluorescence, using the AGE reader, with fasting plasma glucose and glycated hemoglobin for the detection of diabetes mellitus or impaired glucose tolerance, with the use of the short glucose tolerance test as standard.

The aim of the current study proposal is to test the validity of a decision tree focused on skin autofluorescence, and based on the results described above, as a detection tool for diabetes and impaired glucose tolerance in 2 new cohorts, one in an…

Time Resolved Angiography in Cerebrovascular Shunts (TRACS)

The aim of this project is to assess whether 4D-CTA can generate 3D cranial image data sets with sufficient spatial and temporal resolution to enable its use as a diagnostic tool in cerebrovascular pathology and physiology such as arteriovenous…

Association between endothelial glycocalyx volume and cardiovascular risk scores

The principal aim of this study is to examine whether glycocalyx volume, as estimated by SDF-imaging, is associated with cardiovascular risk as estimated by conventional risk scores.

The effect of cervical spinal cord stimulation on the cerebral blood flow

Effect of SCS on CBF

Intra-stomal and sublingual spectroscopy in septic and non-septic Intensive Care patients; effect of Nitroglycerine, Phenylephrine and Norepinephrine.

What is the base-line StO2 reference value in intestinal stoma's. ? Is NIRS a reliable detector of intestinal ischamia ? What is the influence of filling-status on StO2 in the stoma and sublingually ? What is the influence of NTG on StO2 in the…

ELBA Trial
Ellbow arteriovenous fistula versus Basilic Vein transposition for chronic hemodialysis.

The main objective of this study is to show that the basilic vein transposition in the current elderly population is superior to the brachiocubiti fistula in terms of easy cannulation and maturation. Primary outcome is one year patency We will also…

Transport Related Air Pollution, Variance in commuting, Exposure and Lung function

Quantifying the level of exposure to air pollutants during commuting by car, bus and bicycle. And characterizing the health effects caused by short-term exposure to traffic-related air pollution.

What is the relation between stiffness in the affected extremity and functional recovery in CVA-patients?

To demonstrate the relation between the passive stiffness and the functional recovery of the CVA-patients. The passive stiffness will be measured clinicaly and instrumentaly.

An Exploratory, Multi-center, Open-Label, Single-Arm study to evaluate the Discontinuation Effect of Clopidogrel After Drug Eluting Stent (DECADES) on
Inflammatory and Platelet Activation Markers in Subjects Who Are Receiving Low Dose Acetylsalicylic Acid (ASA)

Primary Objective: To assess whether the withdrawal of clopidogrel 12 months after Drug Eluting Stent (DES) implantation leads to an increase in markers of inflammation and platelet activation.Secondary Objectives: To assess the withdrawal of…

Cardiovascular and metabolic health after the challenge of pregnancy: development and evaluation of a strategy of individual health risk appraisal and tailored intervention

1. To develop a postpartum strategy of appraisel of cardiovascular and metabolic health after pregnancies, complicated by PE, IUGR or GD.2. To develop and evaluate the feasibility of a lifestyle intervention strategy.3. To design a study proposal…

Balloon test for iliac vein compression

The objective of this study is to identify whether pelvic collateralisation occurs when a temporary acute obstruction is induced in the left common iliac vein of healthy subjects.

The role of perivascular adipose tissue in the regulation of insulin sensitivity through muscle microvascular recruitment in non-obese and obese individuals

We aim to study the role of PVAT in regulation of vascular function, tissue perfusion and glucose uptake in muscle. We hypothesize that PVAT determines insulin-induced vasoreactivity when studied ex vivo and correlates with insulin-induced…

The role of perivascular adipose tissue in the regulation of insulin sensitivity through muscle microvascular recruitment in individuals with obesity or type 2 diabetes before and after bariatric surgery.

We aim to study the role of PVAT in regulation of vascular function, tissue perfusion and glucose uptake in muscle. We hypothesize that PVAT determines insulin-induced vasoreactivity when studied ex vivo and correlates with insulin-induced…