353 results
- To assess the absorption, distribution, metabolism and excretion of R924548 after a single oral dose- To assess the safety and tolerability of R924548 after a single oral dose
Therefore, we aim to investigate in a pilot trial the effect of SOM230 on predefined endpoints in patients with moderate to severe GO whom have contraindications for prednisolone therapy or decline from prednisolone therapy for other reasons.
To evaluate the safety and tolerability of SC TCZ monotherapy and/or in combination with MTX or other non-biologic DMARDs comprising AEs, physical examination, vital signs, and clinical laboratory assessments, including immunogenicity, in patients…
In this study, the efficacy of different type drugs, on the development of the psoriatic process in the humanized mouse model for psoriasis, will be evaluated. These different, registered drugs intervene at different levels of the psoriatic process…
ln this study the effect of 1 novel compound on the development of psoriasis in the humanized mouse model isinvestigated.
1. To image tissue biodistribution (joints, lymph nodes and internal organs) of rituximab in RA patients by [89Zr]rituximab PET-CT in RA patients with clinically active disease that will start rituximab treatment.2. To investigate whether…
1) The primary objective of this pilot study is to compare the clonal composition of the TCR repertoire in anterior fascicular sural nerve biopsies with the TCR repertoire in peripheral blood of CIDP patients with active disease in order to identify…
Until recently there were only few therapeutic options to treat AS. Efficacy is proven for several tumor necrosis factor (TNF)-blocking agents, including golimumab. 2-8 However, up to now, the efficacy of golimumab treatment on EAMs, like anterior…
Is CMPX-2030 effective in the transplant model of psoriasis
This study has two main objectives:• to evaluate the prevalence of dRTA in pSS using the urinary acidification test with FF and compare this against the gold standard test with AMCL.• to evaluate whether a low BMD is more prevalent in patients with…
In this study the efficacy of a novel monoclonal antibody on the development of psoriasis in the humanized mouse model will be investigated.This experimental compound will be compared with 2 registered drugs, i.e. Humira en Stelara.
To see if the new drug can prevent development of psoriatic changes in the transplant model of psoriasis
Test efficacy of compound B in humanized mouse model of psoriasis.
In this study the dose reponse of compound MT204 on the development of psoriasis in the humanized mouse model is investigated. The efficacy of MT204 is compared to two registered drugs, namely Ustekinumab and Daclizumab.
To see if the new drug can prevent development of psoriatic changes in the transplant model of psoriasis
There is no online self management training yet for young adolescents with a rheumatic disease. Primary objective of this study is the feasibility testing of the online self managementtraining Reuma Uitgedaagd! by the young adolescents whom…
The primary objective is to study changes in synovial inflammation in serial biopsy samples following the administration of abatacept in patients with active rheumatoid arthritis.The secondary objectives of this study are to (I) assess clinical…
The primary objective of the study is to evaluate the long term safety of SAR153191 in patients with RA on top of DMARDs. The secondary objective of the study is finding the percentages of patients who reach ACR20, DAS28 and EULAR response overtime.
to identify high risk groups in need for more specific and appropriate guidance. Also to provide adequate counselling and help.
The goals of this study is twofold:At first we want to gain insight in neurocognitive functioning of children and adolescents (12-18 year) with JSLE.Secondly, we want to adapt and validate a Dutch translation of a short "Quality Life…