17 results
The primary objective of this study is to monitor changes in oral health during a 3.5-month naval mission and once one month thereafter.
The primary objective of the study is to assess the function and effect of deiodinase type 3 in PMN*s and the mechanisms behind its induction following activation of these cells.
to investigate if small nerve fibres are affected in patients with ICU-AW
In this study we aim to develop a predictive model for septic ICU*patients enabling the clinician to make a customized risk stratification and asses the patient*s immune status.
In this study we aim to study the dynamics of biomarkers and to develop a predictive model for septic ICU-patients enabling the clinician to make a customized risk stratification and asses the patient*s immune status.
To determine whether vaccination with γ-irradiated BCG results in a higher cytokine response by monocytes upon restimulation in vitro with infectious pathogens, compared to monocytes before the vaccination.
To investigate the relation between different autonomic function tests in critically ill patients.
In the current proposal, we propose an in vitro study to explore the interaction of malaria infection, the parasitized erythrocyte, and monocyte iron metabolism. We aim to study the role of hepcidin and to explore a) the pathways involved in malaria…
1. Demonstration of the relation between stage of CKD, CMV seropositivity and the presence of CD4+CD28- T cells2. Presence and cytotoxic potential of CD4+CD28- T cells in the peripheral blood of patients with endstage CKD and the relation with…
Primary objective is to assess in vivo neuroinflammation quantitatively in patients with sepsis. Secondary objective is to study whether differences in in vivo neuroinflammation are related to long term cognitive outcomes.
With this study we aim to provide insight in the role of pulmonary RAS in the pathogenesis of ARDS in neonates and children. This study is performed in the context of a comparative study assessing the impact of age on the pulmonary RAS in ARDS. We…
Primarily, we aim to identify SNPs and transcripts that are associated with the degree of endotoxin tolerance. To increase the chances of success, the genomic and transcriptomic data obtained in vivo will be integrated with data obtained by a…
Primary Objectives• Employ a systems biology approach to identify a set of candidate biomarkers (BM) in circulation and/or pathways & mechanisms that correlate with particular non-AIDS defining comorbidities (ie NASH, CVD) in HIV+…
Overall aimThe overall aim is to assess whether associations can be identified between the presence of oral/dental foci, the composition of the oral microbiome, the incidence and severity of OM, and the risk to develop FN in cancer patients treated…
We aim to analyze AMs of healthy volunteers using an integrative approach. Combining functional and phenotypical analyses with -omics based techniques can discover relationships across several cellular modalities, hereby providing an integrative…
In this study we aim to investigate which pathways in septic patients exacerbate endothelial injury and dysfunction, furthermore do we want to investigate to what extent, and due to which components plasma transfusion can improve the endothelial…
To determine the effect of transfusion on the expression of PS in critically ill patients with and without inflammation.