17 results
Experimentally, develop a software algorithm to objectively assess the microcirculation quality of the colorectal wall, intraoperative, by laparoscopy to predict the probability of developing anastomotic leakage, with the intention to develop a…
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This study aims to assess the efficacy and potency of newly developed small molecule inhibitors of the GC-C signaling pathway and of the CFTR chloride channel in native human intestinal tissue.
To assess the involvement of a specific genetic risk allele on oxidative stress induced by neutrophils in relation to H. pylori infection.
Primary Objective: To determine the sensitivity and specificity of MRI in a consecutive series of adult patients suspected for acute appendicitisSecondary Objective(s): Is MRI of additional value in adult patients with inconclusive US? And is…
To determine the prevalence of T. whipplei in duodenum and colon in a random population of patients whom will undergo an endoscopy at the VUmc
1.What are ulcerative colitis patients* understanding of their risk of colon cancer and the benefit of colonoscopy?2. What is ulcerative colitis patients* threshold of cancer risk before accepting colectomy in the setting of dysplasia?3. What are…
To determine the value of MRI in a consecutive series of pediatric patients suspected for acute appendicitis
In case of food- or water related outbreaks of bacterial gastroenteritis, the regular research of Municipal Health Services (GGD) and the Food and Consumer Product Safety Authority (VWA) aims at control of the outbreak.The aim of this project is to…
To determine the usefulness of multiplex real-time pcr to detect asymptomatic parasitic infections in travellers returning from the tropics.
Primary objective:To determine the incidence of Clostridium difficile infection (CDI) in hospitalized patients aged * 50 years old and receiving oral or intravenous fluoroquinolones, cephalosporins, penicillins + beta-lactamase inhibitors,…
Primary: To determine fecal calprotectin in patients treated with checkpoint inhibitors. Secondary: To describe endoscopic and histologic findings in patients with symptoms that may indicate colitis.To study cytokine production profiles of the…
To evaluate the accuracy of H. pylori determination in FIT
This study will assess whether alginate oligomers enhance the efficacy of anti-diarrheals, i.e. compounds that block intestinal ion and water secretion.
Primary Objective: In accordance with the original study, the primary endpoint is composite of mortality and major morbidity. Major morbidity is defined as new onset organ failure (cardiac, pulmonary or renal), bleeding requiring intervention,…
Primary objective of the study is to determine whether prolonged use of 96 hours leads to growth of microorganisms (type and numbers (CFU/ml)) in enteral tube feeding sets. Secondary objectives are the occurrence of gastrointestinal events/ new…
Primary objective: To establish a controlled human infection model for C. difficile which is safe, well tolerated and results in microbiological and clinical endpoint in ideally >=70% of volunteers. Secondary objectives:- Assess colonisation…