68 results
Distinguishing frontal lobe epilepsy from ADHD in terms of working memory.
The aim of this research is, following the aforementioned theoretical framework, to investigate whether the two candidate genes in combination with EEG and fMRI markers differentiate between children that do and do not show a clinical response to…
Purpose of the study is to investigate neurocognitive and behavioral development in children of morthers with epilepsy, primary school age, and who were exposed to anti-epileptic drugs in utero. Primary research questions are: 1. what is the nature…
The proposed study aims to bring neuroimaging and genetics closer to the child/adolescent psychiatric clinic by developing automated classifiers, and obtain associated multimodal biomarker profiles. Such biomarkers are prospected to, aid in clinical…
To objective of this protocol is threefold.1. To investigate transdiagnostic cognitive deficits across a diversity of different psychiatric disorders.2. To link cognitive deficits with symptom-dimensions, EEG, cortisol, genetic and other blood…
Previous studies have suggested an association between FD and cognitive impairment but these were flawed either by lack of power, used variable assessment of cognitive functioning and/or merged results of different phenotypes and sexes. It is of…
Objective: The primary objective of this study is to investigate whether pain experience decreases or increases when cognitive functions decline in patients with Parkinson's disease. Furthermore will be investigated whether this is influenced…
To identify brain determinants (moderators) and mechanisms (mediators) of ADHD persistence into adulthood by studying fine-grained neuroanatomy and connectivity in a longitudinal study of genetically stratified patients across the full spectrum of…
The purpose of the study is to investigate how quickly and to what extent RO5285119 is absorbed from the gut and then eliminated from the body (this is called pharmacokinetics).It will also be investigated to what extent RO5285119 is tolerated.
The main objective is to explore the effects of mulimodal treatment upon empathic skills in forensic male adolescents with ADHD, with or without DBD. A secundair objective is to explore the effects of multimodal treatment upon antisocial behavior.
Here we propose that in order to identify causal mechanisms that explain AD/HD-related heterogeneity, an integrative approach is needed. Therefore, in this project we will study the interaction between motivation and executive function in AD/HD and…
Primary: to study the frequency and characteristics of fatigue and cognitive disorders after minor stroke. Secondary: to gain more insight in the aetiology of post-stroke fatigue and evaluate the impact of post-stroke fatigue on personal and social…
To determine the effects of surgical and transcatheter (transapical, transfemoral or transaortal) aortic valve replacement on patient neuropsychological functioning which provides the opportunity to prematurely establish subclinical effects that may…
1) to investigate cognitive functioning in lacunar infarct patients with and without periventricular white matter lesions; 2) to identify predictors for cognitive dysfunction in lacunar infarct patients.
Main Objective: - to validate the identified cognitive profiles prospectively in a new population using confirmatory cluster analysisSecondary Objectives: - to identify the clinical and demographical factors associated to the identified cognitive…
- The primary objective of this proposal is to assess the intraindividual reliability of PAS TMS, Theta-burst rTMS and ppTMS indices as measures of neural plasticity and cortical inhibition, by performing test-retest measurements separated by a…
1) to investigate whether hypertensive patients with WMLs decline more strongly in cognitive function than hypertensive patients without WMLs in a 4-year time period. 2) to identify predictors for cognitive dysfunction in hypertension/SVD patients.
The objective is to assess the gait characteristics of adults with intellectual disabilities by other causes than Down syndrome, and without diagnosed neurological conditions (Parkinson's disease, cerebrovascular accident, dementia, and…
The aim of this study is to test the feasibility, reliability and validity of a Dutch version of the Penn Computerized NeuroPsychological testing system (CNP). It is tested wether our translated version is feasible for use in the Dutch population at…
The primary objective of this study is to provide access to SPD503 following participation in SPD503-315 or SPD503-316. The primary outcome of this study is to evaluate the long-term safety of SPD503. The evaluation of safety will be based on the…