143 results
The primary objective is to asses the association between the EELV measured with RIP and EELV volume measured with electrical impedance tomography (EIT). Secondary objectives include a) studying the association between the EELV measured with RIP and…
Primary Objective: To investigate the safety and feasibility of re-treating patients with COPD with the RePneu LVRC system.Secondary Objective: To investigate the effectiveness of re-treating patients with COPD with the RePneu LVRC system on lung…
The aim of this extension trial is to provide BIBF 1120 treatment for all patients who have completed the 52 weeks treatment period and the follow up period in the phase III placebo controlled parent trial 1199.34, who may have experienced benefit…
The general objective of the Doetinchem Cohort Study is to contribute to the answering of public health questions, now and in the future, by providing basic data on developments in lifestyle and health problems in the general Dutch population.
Objective:1. To describe the prevalence and incidence of *difficult-to-treat* adult asthma in the Netherlands.2. To describe factors associated with adherence with pulmonary medication in patients with difficult-to-treat airway disease. 3. To…
The primary objective of this study is:• To compare the rate of moderate-severe COPD exacerbations in COPD patients with and without cardiovascular diseases (CVD) The secondary objectives are:• To compare the rate of moderate-severe COPD…
The primairy objective of this study is to investigate how many children who where diagnosed with episodic viral weeze by a hospital-based paediatrican have astma at the age of 6-8 years. The secundary objective of this study is to examine the…
Comparing the metabolic response (oxygenuptake and ventilation) and symptom perception (borgscores for dyspnoea and fatigue) between neuromuscular electrical stimulation with low-frequency and high-frequency.
to offer continuation of BIBF 1020 treatment for patients with IPF who have completed a prior clinical trial with that drug.establish the long term tolerability and safety profile of BIBF 1120 in IPF.
This observational study is designed to test the hypothesis that the Bicore-IITM technology may act as a useful bedside tool during lung recruitment, as well as a tool in the differentiation between lung overdistension or a worsening of disease…
The objective of the current study is to investigate the individual sensitivity for the development of ILD after exposure to various triggers. Main focus will be the differences in the formation of and the protection against ROS as well as the…
The primary objective is the Objective tumor response rate (RECIST). Secondary objectives are: duration of overall response, time to tumor progression (TTP), progression free survival (PFS), overall survival, toxicity profile, incidence of…
To determine feasibility and reproducibility of MicroRint pulmonary function testing in 50+ people with different levels of intellectual disability.
The objective of RAKKER2 is to study is, in terms of implementation, to get insight in the question 'to whom' a multifaceted primary prevention program should be offered. Therefore, in this study the predictive value of family history of…
Exploring the incidence of fatigue after sarcoidosis, its severity and nature. Next we will try to associate fatigue with capacity to produce pro- and anti-inflammatory cytokines.Our secondary objective is testing the activity of the HPA-axis, the…
The aim of this study is to investigate if there are genetic factors predisposing to Löfgren*s syndrome, and whether these factors have an influence on the clinical course.
The primary objective of this current proposal is to test validity of the MPH test to detect DH. Validity is analyzed by comparing MPH-induced DH with DH induced by a symptom-limited incremental cycle exercise test.
The objective of this study is to evaluate the safety and device performance of the Portaero Pneumostoma System to create and maintain a transthoracic pneumostoma in patients with severe emphysema and hyperinflation.
This pilot study will investigate whether patients with both COPD and CHF who participated in a community based reactivation programme have a higher exercise capacity and a better health related quality of life after the programme in comparison with…
To assess whether the GdMRI can fit in the annual check up.To assess whether the GdMRI is sensitive to monitor and follow up on the peripheral bronchiectasis and areas of hypoperfusion. To compare the distribution and volume of hypo perfusion on…