141 results
The purpose of this study is to improve the prediction of RD episode in patients undergoing opioid therapy in the hospital ward (also known as the General Care Floor) to guide clinicians and nursing staff in selecting the at-risk patients who could…
Comparing the metabolic response (oxygenuptake and ventilation) and symptom perception (borgscores for dyspnoea and fatigue) between neuromuscular electrical stimulation with low-frequency and high-frequency.
The primairy objective of this study is to investigate how many children who where diagnosed with episodic viral weeze by a hospital-based paediatrican have astma at the age of 6-8 years. The secundary objective of this study is to examine the…
The objective of the current study is to investigate the individual sensitivity for the development of ILD after exposure to various triggers. Main focus will be the differences in the formation of and the protection against ROS as well as the…
to offer continuation of BIBF 1020 treatment for patients with IPF who have completed a prior clinical trial with that drug.establish the long term tolerability and safety profile of BIBF 1120 in IPF.
The primary objective of this current proposal is to test validity of the MPH test to detect DH. Validity is analyzed by comparing MPH-induced DH with DH induced by a symptom-limited incremental cycle exercise test.
1. Respiratory physiologyDoes severity of ventilatory impairment during ADL increase in patients with respectively COPD GOLD stages II, III and IV?2. Systemic inflammationDo ADL in COPD patients lead to an increase in systemic inflammatory markers?
To assess long-term safety and tolerability of bosentan in patients with IPF.
Research questions:What is the current prevalence of latex allergy among operating room employees from Erasmus Medical Centre, Rotterdam? Is the sensitisation prevalence significantly lower compared to the prevalence before introducing non powdered…
The objective of RAKKER2 is to study is, in terms of implementation, to get insight in the question 'to whom' a multifaceted primary prevention program should be offered. Therefore, in this study the predictive value of family history of…
The aim of this study is to investigate if there are genetic factors predisposing to Löfgren*s syndrome, and whether these factors have an influence on the clinical course.
The objective of this study is to evaluate the safety and device performance of the Portaero Pneumostoma System to create and maintain a transthoracic pneumostoma in patients with severe emphysema and hyperinflation.
This pilot study aims to investigate sexual wellbeing, sexual functioning and sexual health care need within four groups of patients with major illness (COPD patients, gynaecological patients, pelvic care patients, and patients with depressive…
This pilot study will investigate whether patients with both COPD and CHF who participated in a community based reactivation programme have a higher exercise capacity and a better health related quality of life after the programme in comparison with…
Clarify the effect of 5T polymorphism with or without another CF causing mutation on the other allele, on the CFTR function.
The Activation of Coagulation and Inflammation in Trauma (ACIT) study is designed to identify the clinically significant mechanisms and pathways by which inflammation and coagulation are activated immediately following major trauma, and how these…
The purpose of this trial is: • to study the effect of a single dose of GAL-054 (the test medication) in healthy volunteers on the functioning of the body, especially on respiration, and compare this with the effect of a single dose of doxapram.• to…
Objective:1. To describe the prevalence and incidence of *difficult-to-treat* adult asthma in the Netherlands.2. To describe factors associated with adherence with pulmonary medication in patients with difficult-to-treat airway disease. 3. To…
The primary objective is to establish the point prevalence of Airflow Limitation (AL) compatible with COPD in patients with congestive heart failure (CHF) seen in a single centre in the Netherlands.
The aim of this extension trial is to provide BIBF 1120 treatment for all patients who have completed the 52 weeks treatment period and the follow up period in the phase III placebo controlled parent trial 1199.34, who may have experienced benefit…