78 results
The overall aim of the study is to improve diagnostic and therapeutic options for people with CF, especially in the context of young children and novel CFTR-targeting drugs. Primary Objective: 1. to demonstrate relations between CFTR genotype,…
The primary objective of this study is to determine the Optical Density Ratio (ODR) for the prototype CORIMAP camera and compare the ODR values with the Oxymap T1 mounted on a regular fundus camera in a healthy adult population. For comparison, it…
To evaluate whether blood CC12gene expression defines disease status (Stage I-IV, stable or progressive) and whether the blood CC12gene expression predicts response to therapeutic intervention.
The main objective of the panel study is to evaluate the associations between short-term variation of concentrations of key air pollutants (NO2, PM2.5, PM10, and ultrafine particles), measured on a fine spatial and temporal resolution, and short-…
Is the application of CryoSeal (CS) in primary total knee replacement surgery beneficial for the patient with respect to a faster track and improved postoperative rehabilitation. The beneficial effect may be due to quicker functional knee…
Primary: Progression free survival.Secondary: Toxicity, overall survival, response rate, duration of response, translational research.
To investigate whether high resolution multi-site epicardial mapping of the atria in patients with structural heart disease undergoing cardiac surgery can identify patients at risk for developing early post-operative atrial fibrillation. The…
To demonstrate differences in neuronal structure and neuronal function in brain regions that control eating behaviour between obese and normal weight adolescents.
Intermittent neurogenic claudication due to lumbar stenosis is frequently diagnosed among older persons. Due to an aging population it is to be expected the incidence of lumbar stenosis will increase over time. Patients are operated on because of…
Objective of this study is to determine the prevalence of vitamin B12 deficiency among patients who underwent esophagectomy with GTR. The following specific research questions heve been defined:- What is the prevalence of vitamin B12 deficiency in…
Optimization of a recently developed 3T MRI protocol for imaging of the coronary and aortic vessel wall.
Primary ObjectiveThe primary objective of this study will be to compare the efficacy of infliximab with that of placebo in the prevention of clinical recurrence of CD through Week 76, defined as a composite endpoint that requires endoscopic…
(1) To assess the effect of ARA 290 on the ventilatory response to hypoxia (and compare the effects to Epo); (2) To assess the effect of ARA 290 on the gradient over the tricuspid valve during hypoxia (and compare the effects to Epo); (3) To assess…
In this study we will evaluate the effect of Sunshower Medical device at home and compare it with the effect of customary UV hardening performed in the hospital to assess whether the former is not inferior to the latter treatment. The ultimate goal…
1. Do body fatness and/or body fat distribution show a linear association withmicrovascular function in normal as well as IGT subjects?2. Is the effect of body composition on the microvasculature mediated by alteredadipokine profile, low-grade…
To investigate the clinical feasibility of the Provox StabiliBase adhesive.
The aim of this study is to investigate whether weeklong dietary intake of estrogens via high cow*s milk consumption in the Dutch population increases systemic estrogen concentrations. To this aim, estrogen levels are measured in urine samples of…
To compare the effects on the APC- (Activated Protein C) resistance ratio (ETP-[endogenous throbin potential] based) between the pivotal phase III NOMAC-E2 batch and a commercial NOMAC-E2 batchTo compare the effects on all other metabolic parameters…
The determination of the energy expenditure in wheelchair-bound children in rest, during daily activities, and during therapeutic horseback riding.
The aim of this study is to compare Eye Movement Desensitization and Reprocessing (EMDR), with an empirically proven effective treatment, namely Cognitive Behavioral Therapy (CBT) in the treatment of panic disorders with or without agoraphobia. The…