Search for a trial

The use of Fibrin sealant In total knee Replacement Surgery Trial. A prospective randomised multicentre study.

Is the application of CryoSeal (CS) in primary total knee replacement surgery beneficial for the patient with respect to a faster track and improved postoperative rehabilitation. The beneficial effect may be due to quicker functional knee…

Phase II Study of Docetaxel, Oxaliplatin, Capecitabine with Bevacizumab and Trastuzumab in case of human epidermal growth factor receptor 2 (HER2)-positivity in Patients with Locally Advanced or Metastatic Gastric Cancer or Adenocarcinoma of the Gastro-oesophageal Junction (B-DOCT study)

Primary: Progression free survival.Secondary: Toxicity, overall survival, response rate, duration of response, translational research.

Epicardial Mapping Studies in Patients undergoing Cardiac Surgery
Roepnaam Quasar

To investigate whether high resolution multi-site epicardial mapping of the atria in patients with structural heart disease undergoing cardiac surgery can identify patients at risk for developing early post-operative atrial fibrillation. The…

Neuroimaging of childhood obesity: a case control study

To demonstrate differences in neuronal structure and neuronal function in brain regions that control eating behaviour between obese and normal weight adolescents.

(Cost) Effectiveness of Surgery versus Prolonged Conservative Treatment in Patients with Intermittent Neurogenic Claudication caused by Lumbar Stenosis

Intermittent neurogenic claudication due to lumbar stenosis is frequently diagnosed among older persons. Due to an aging population it is to be expected the incidence of lumbar stenosis will increase over time. Patients are operated on because of…

Vitamin B12 deficiency after esophagectomy with gastric tube reconstruction.

Objective of this study is to determine the prevalence of vitamin B12 deficiency among patients who underwent esophagectomy with GTR. The following specific research questions heve been defined:- What is the prevalence of vitamin B12 deficiency in…

Optimization of a new 3 Tesla Magnetic Resonance Imaging protocol to vizualize the coronary arteries and aorta

Optimization of a recently developed 3T MRI protocol for imaging of the coronary and aortic vessel wall.

Prospective, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Comparing REMICADE® (infliximab) and Placebo in the Prevention of Recurrence in Crohn*s Disease Patients Undergoing Surgical Resection Who Are at an Increased Risk of Recurrence

Primary ObjectiveThe primary objective of this study will be to compare the efficacy of infliximab with that of placebo in the prevention of clinical recurrence of CD through Week 76, defined as a composite endpoint that requires endoscopic…

ARA 290 and the ventilatory response to hypoxia and pain responses in healthy volunteers

(1) To assess the effect of ARA 290 on the ventilatory response to hypoxia (and compare the effects to Epo); (2) To assess the effect of ARA 290 on the gradient over the tricuspid valve during hypoxia (and compare the effects to Epo); (3) To assess…

Sking hardening in polymorphic light eruption. Comparison of therapeutic effect of UVB hardening in the hospital with treatment at home with Sunshower

In this study we will evaluate the effect of Sunshower Medical device at home and compare it with the effect of customary UV hardening performed in the hospital to assess whether the former is not inferior to the latter treatment. The ultimate goal…

New Hoorn Study:
*Cause and consequences of disturbed microcirculation: effects of glucose tolerance status*

1. Do body fatness and/or body fat distribution show a linear association withmicrovascular function in normal as well as IGT subjects?2. Is the effect of body composition on the microvasculature mediated by alteredadipokine profile, low-grade…

Clinical Feasibility of a new adhesive base plate (placeholder for stoma appliances) for rehabilitation after total laryngectomy

To investigate the clinical feasibility of the Provox StabiliBase adhesive.

Effects of cow*s milk consumption on estrogen levels in human male volunteers

The aim of this study is to investigate whether weeklong dietary intake of estrogens via high cow*s milk consumption in the Dutch population increases systemic estrogen concentrations. To this aim, estrogen levels are measured in urine samples of…

A randomized, open-label, comparative, multicenter trial to compare the effects on metabolic parameters of two NOMAC-E2 batches (pivotal phase III and commercial batch) and a monophasic COC containing 150 µg LNG and 30 µg EE (Phase III, Protocol No. P06447)

To compare the effects on the APC- (Activated Protein C) resistance ratio (ETP-[endogenous throbin potential] based) between the pivotal phase III NOMAC-E2 batch and a commercial NOMAC-E2 batchTo compare the effects on all other metabolic parameters…

Is Therapeutic Horseback Riding Effective in Order to Stimulate Physical Activity and Fitness in Wheelchair-bound Children? A Pilot Study

The determination of the energy expenditure in wheelchair-bound children in rest, during daily activities, and during therapeutic horseback riding.

Eye Movement Desensitisation and Reprocessing (EMDR) versus Cognitive Behavioral Therapy (CBT) in the treatment of panic disorders with or without agorafobia: A Randomized Controlled Trial.

The aim of this study is to compare Eye Movement Desensitization and Reprocessing (EMDR), with an empirically proven effective treatment, namely Cognitive Behavioral Therapy (CBT) in the treatment of panic disorders with or without agoraphobia. The…

Safety and efficacy of the addition of simvastatin to cetuximab in k-ras mutant advanced or metastatic colorectal cancer patients.
A single-arm, multicenter, phase II study using a Simon two stage design.

Primary objective is to investigate the percentage of patients with k-ras mutant advanced or metastatic colorectal cancer free from progression and alive after 12.5 weeks after the first dose of cetuximab (i.e., 14 weeks after the scan at baseline…

Cost-effectiveness of treatment strategies for intermittent claudication

To evaluate the cost-effectiveness, from the perspectives of the health care system and of society at large, of supervised exercise compared to endovascular revascularization plus supervised exercise as first-line treatment of IC.

Radiotherapy of the breast: prone versus supine position. A planning study

To compare dose homogeneity and heart and lung doses in supine and prone position. Furthermore, the reproducibility of prone position will be compared to standard supine position, and we aim to identify those patients who benefit most from prone…

Functional MRI of food temptations: Effects of temptation exposure on the activation of reward and conflict areas in the brain.

Our main objective is to compare the effects of weak and strong food temptations on the activation of reward and conflict areas in the brain.