91 results
The primary goals of this study are to: i. Identify genetic variations responsible for PLP across the whole genomeMore than 90% of SNPs are found in introns or intergenic regions and most of them are probably of little functional consequence.…
The aim of Prevent CardioKids is to evaluate to what extend disturbed vascular function markers are present in children of different weight categories and whether these are age dependent. Also differences * and relationships between * vascular…
Determining the role of duplex ultrasound in patients with a clinical suspicion for temporal arteritis.Determing the sensitivity, specificity, negative predictive value and positive predictive value of duplex ultrasound in patients with a clinical…
To evaluate the post-market performance of the GORE® VIABAHN® Endoprosthesis for the treatment of in-stent restenosis in the superficial femoral artery.
We hypothesize that the amount of physical activity correlates with insulin-induced microvascular recruitment during free-fatty acid infusion in skeletal muscle as well as in the heart. In this study we aim to test this hypothesis.
This study aims at (further) revealing the pathophysiology of intestinal IR in man, with a specific interest for the role of proteases and protease-activated receptor-2 (PAR-2), cellular and inflammatory changes, barrier function and intestinal…
Aim of the study is to determine the microvascular function in type 1 diabetes patients with concomitant celiac disease
The primary aim of this study is to investigate the recovery of the circadian rhythm of the hypothalamic-pituitary-adrenal axis during a glucocorticoid tapering regime. Secondary objectives include the effect of a tapering regime on melatonin rhythm…
This study aims to investigate the sensitivity and specificity of the history and physical examination for the diagnosis of giant cell arteritis, compared with the superficial temporal artery biopsy, and get more insight into the positive and…
1. To identify presymptomatic and symptomatic profiles including (early) disease stages and early biomarkers of disease progression and to elucidate pathophysiological mechanisms, we will investigate RVCL patients at different ages (both symptomatic…
To determine the effect of a single red blood cell transfusion on the microcirculation.
Measuring the thickness of the microvascular glycocalyx, and make a comparement between lacunar stroke patients and healthy controls.We also compare glycocalyx between patients with and without concomitant silent signs of cSVD on brain MRI.
The main point of this study is to detect in a controlled fashion if there is a relationship between CCSVI and MS. We focus on 5 parameters indicative of CCSVI: 1-reflux in the internal jugular vein (IJV) or in the vertebral vein (VV), or both with…
1. Validate and adjust the current classification criteria for systemic vasculitis2. Develop and validate new diagnostic criteria for systemic vasculitis
To develop pulse transit time into a diagnostic device which can be used to assess an altered cold/heat mediated vasomotor response (CHMV) (central component) and the flow-mediated dilatation (FMD) (peripheral component) in CRPS patients.
The primary objectives of the study are to assess the prevalence of large artery inflammation in patients with temporal arteritis or an unexplained inflamatory response and the diagnostic utility of 18FDG-PET/CT in patients with an unexplained…
1. Do body fatness and/or body fat distribution show a linear association withmicrovascular function in normal as well as IGT subjects?2. Is the effect of body composition on the microvasculature mediated by alteredadipokine profile, low-grade…
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The aim of the current study proposal is to test the validity of a decision tree focused on skin autofluorescence, and based on the results described above, as a detection tool for diabetes and impaired glucose tolerance in 2 new cohorts, one in an…
This study is designed to determine the vessel wall inflammation in patients with extreme levels of one traditional risk factor.