110 results
To assess the short-term efficacy of stellate ganglion block on hot flush reduction versus sham procedure
Our main aim is to describe the 24-h circadian rhythm of skin and core body temperature in people with SCI and examine whether changes in melatonin and/or cortisol relate to the altered circadian rhythm in core body temperature recently described in…
Do high plasma free fatty acids lower central serotonergic responsivity?
The primary objective is to study the effects of GH substitution therapy in adult GH deficient survivors of childhood cancer. Primary endpoints are organ size, renal function and capillary density of the skin.
ObjectiveTo assess the prevalence of PHD and chronic fatigue in Dutch TBI patients, and to study the relationships between the various aspects of chronic fatigue and PHD, with particular emphasis on the association between chronic fatigue, and…
To document cardiac function before and after treatment of CS.
The objective of the study is to improve medical treatment of Cushing's disease by combining partially independent medical therapies which act through differential mechanisms. Given the high affinity of SOM230 to sst5 and considering the facts…
Primary objectivesTo evaluate the prevalence, and incidence in yearly intervals, of pituitary insufficiency after cranial irradiation or total body irradiation at long-term follow-up. Secondary objectiveTo evaluate the impact of cranial irradiation…
Primary objective: To evaluate whether patients with a prolactinoma have signs of altered vascular function and/or morphology in the retina or sublingual tissues in comparison to healthy controls. Secondary Objectives: 1. To evaluate whether there…
To evaluate whether GH substitution in patients with an isolated GHD after TBI could reverse the severity of symptoms which characterize GHD.
Aim of the study is to study the influence of GH receptor polymorfisms on the effects of growth hormone substitution in aduts with GH deficiency.
Hypothesis:1. Patients who suffer from a hypopituitarism and an adult-onset growth hormone deficiency (AGHD) express more atherosclerotic disease in the coronary system (compared with a historically formed control subjects, present as a database in…
Whether cognitive functions in SGA children are impaired due to inappropriate developmental outgrowth in children born with a low birth weight is unknown. This is also the case for the fact whether GH treatment from the age of 4 years is still…
Comparing the reliability of a dietary-protein test with conventional Growth Hormone Stimulation Tests.
To identify risk factors that might contribute to the development of post-traumatic HHD in children in order to reduce the lag-time between onset and diagnosis for future patients. To investigate the level of functioning and the quality of life of…
Does bilateral deep brain stimulation of the subthalamic nucleus in patients with Parkinson's disease influence plasma triglycerides and glucose metabolism?
The following research questions will be addressed: 1.Is there irreversible joint damage after previous GH excess in long-term cured acromegalic patients?2.What are the clinical characteristics of reported joint problems on clinical examination? 3.…
To determine whether hypothalamic response to glucose ingestion in patients with anorexia nervosa differs from that in healthy subjects.
(1) To establish the pharmacokinetic profile of clonidine following oral administration in children with suspected GH deficiency. (2) To relate the pharmacokinetics of clonidine to the observed expected (GH-response, cortisol response, depth and…