34 results
To characterize the interaction between the gut microbiome, related metabolites, immune function, and perceived complaints in QFS-patients, CFS-patients, and healthy individuals.
The primary objective of this study is to monitor changes in oral health during a 3.5-month naval mission and once one month thereafter.
The primary objective of the study is to assess the function and effect of deiodinase type 3 in PMN*s and the mechanisms behind its induction following activation of these cells.
The aim of this study is to explore the prevalence of HAND in people living with HIV.
The aim of this study is to create a prognostic model enabling the clinician to predict the outcome of a septic episode. Furthermore, by getting more insight in the pathophysiologic proces of sepsis, we could discover new possible targets for future…
The aim of the study is to explore the prevalence of HAND in people living with hiv.
to investigate if small nerve fibres are affected in patients with ICU-AW
In this study we aim to develop a predictive model for septic ICU*patients enabling the clinician to make a customized risk stratification and asses the patient*s immune status.
In this study we aim to study the dynamics of biomarkers and to develop a predictive model for septic ICU-patients enabling the clinician to make a customized risk stratification and asses the patient*s immune status.
Primary Objective: To study stimulating effects of prolonged (8h) enteral L-citrulline supplementation on the normalisation of the Arginine-NO metabolism.Secondary Objective: To study stimulating effects of prolonged (8h) enteral L-citrulline…
To evaluate the effect of age of transfused erythrocytes on expression of *eat me* signals on erythrocytes in several critically ill patient populations (septic and non-septic patients) and to correlate these signals with parameters of impaired…
To study the relationship between (a) abnormal concentrations of plasma amino-acids, pterins, HVA and inflammatory parameters and (b) the severity, duration and outcome of delirium. To find a biochemical profile that predicts the occurrence of a…
To determine whether vaccination with γ-irradiated BCG results in a higher cytokine response by monocytes upon restimulation in vitro with infectious pathogens, compared to monocytes before the vaccination.
To investigate the relation between different autonomic function tests in critically ill patients.
Objective of this study is to provide evidence for the induction of AGEs in blood and tissue in patients with septic shock.
The primary objective of the study is to determine concentration of circulation cytokines na administration of LPS in the presence of iron sucrose (Venofer®), Deferasirox (Exjade®) of placebo.
In the current proposal, we propose an in vitro study to explore the interaction of malaria infection, the parasitized erythrocyte, and monocyte iron metabolism. We aim to study the role of hepcidin and to explore a) the pathways involved in malaria…
The primary objective of this study is to demonstrate that eritoran tetrasodium treatment of patients with severe sepsis results in a reduction in 28-day all-cause mortality.The secondary objectives are to confirm eritoran*s safety profile, and to…
1. Demonstration of the relation between stage of CKD, CMV seropositivity and the presence of CD4+CD28- T cells2. Presence and cytotoxic potential of CD4+CD28- T cells in the peripheral blood of patients with endstage CKD and the relation with…
Primary objective is to assess in vivo neuroinflammation quantitatively in patients with sepsis. Secondary objective is to study whether differences in in vivo neuroinflammation are related to long term cognitive outcomes.