15 results
The primary objective is to study glaucomatous structural brain changes in a longitudinal manner, and how it relates to visual functional loss and glaucomatous retinal changes over time.
To demonstrate that externally induced increases in epipalpebral pressure (EPP) relate to clinically significant increases in IOP, and to determine posture dependency of EPP. To determine the effects of protective goggles on EPP under these…
In the present study, we will investigate if a monocular visual field defect - due to primary open angle glaucoma - influences the anatomical integrity of the visual pathways.
To demonstrate that externally induced increases in subpalpebral pressure (SPP) relate to clinically significant increases in IOP, and to determine posture dependency of SPP. To determine the effects of protective goggles on SPP under these…
To determine the effect of tube position in the anterior chamber on the corneal endothelium.
The aim of this study was to test these biomarkers of NO in glaucoma patients both with and without tinnitus. The objective was also to replicate findings from a previous study performed in Amsterdam, a collaboration between our research group and…
The goal is to study the genetic background of childhood glaucoma in the Netherlands. We aim to study which mutations play a role in the pathogenesis of childhood glaucoma in the Netherlands and their prevalence. We will study the genetic mutations…
Main objectives: 1. Determine whether the POAG patients with low values of the blood mtDNA copy number have a low mtDNA copy number and low mitochondrial function in skin fibroblasts, using in vitro assays of mitochondrial function.2. Explore the…
The primary objective is to evaluate changes in ICP due to acetazolamide using a noninvasive method of ICP measurement and to compare this with changes in IOP. Healthy controls will be used to control for any effect of diurnal fluctuations.
The objective of this study is to compare OCT-A findings between five groups of non-glaucomatous subjects characterised respectively by a) low symptomatic, b) low asymptomatic, c) normal asymptomatic, d) untreated high asymptomatic, and e) treated…
To examine the presence of structural and functional brain changes in glaucoma patients. Specifically, we are interested in the presence of glaucomatous functional brain changes that are beyond those that can be explained on the basis of propagated…
The aims of this study are (1) to determine if ear absorbance can be used to non-invasively measure ICP and (2) to determine if ICP differs between glaucoma patients and controls.
Primary Objective: The primary objective is to evaluate the use of DPOAEs as a representation of ICP in Glaucoma patients by investigating changes in DPOAE amplitudes and phase angles with changes in posture in subgroups of glaucoma patients and in…
The primary objective of this study is to be able to better assess progression of visual pathway damage in advanced glaucoma cases in particular. For this, we will use a unique combination of OCTA and dMRI techniques. In particular, we aim to relate…
The overall aim of the Ageinglines cohort study is to better understand the biological ageing process and its association with the onset (pre)frailty and well-being in later life and to identify targets for delaying the biological ageing process…