557 results
1. To examine whether there is an increase in (nigro)striatal dopaminergic functioning in individuals of West-African descent relative to those of Dutch descent (assessed in older participants with DAT SPECT and with NM-MRI in the entire sample). (…
In this study, we aim to describe cognition and behaviour in patients with DS and analyse correlations between behavioural difficulties and various characteristics including: seizure severity; medication use; level of cognitive functioning; and…
EDGI aims to enhance the understanding of the underlying biology and genetic architecture of the different eating disorders. Therefore GWA analyses (both within and cross disorder analyses) will be performed in the EDGI samples combined with the PGC…
The iBerry Study has two main study objectives:1. Descibing long-term prognosis of subclinical symptoms in terms of course (transition to several psychiatric disorders, chronicity, recurrence, comorbidiy) and public health consequences (disability,…
The main objective of CRUCIAL-VCI is to determine a surrogate MRI marker for microvascular density in patients with VCI due to cSVD, and to relate this to disease severity expressed as macrostructural brain damage and cognitive function. The…
We aim to assess the association between variability and irregularity in heart rate (as caused by permanent atrial fibrillation), and cognitive function. In addition, variability and irregularity of the peripheral blood pressure will be correlated…
Primary objective:- to determine the association of the intra-individual determinants and the physical environment in regulating lifestyle behaviour and in turn the occurrence of pre-T2D and T2D in the general population. Secondary Objective(s): -…
First aim is to quantify DA function of meso-limbic/cortical DA pathways (measured with 18F-FE-PE2I Position Emission Tomography (PET) in PD-depression with or without anhedonia (vs. non-depressed PD). Second aim is to associate these DAT findings…
The aim of this study is to combine acoustic characteristics from spontaneous speech and results from tests at different linguistic levels e.g. the Diagnostic Instrument for Mild Aphasia (DIMA), to determine which aspects in speech are most…
Primary Objectives: 1. To investigate the nature and extent of persistent fatigue and cognitive complaints 2. To investigate the impact of persistent complaints on health-related quality of life and health care consumption3. To identify risk factors…
(a) investigate long term functional outcomes of ADHD; *(b) identify factors that predict a favourable as well as non-favourable outcome/trajectory of ADHD;(c) investigate long term effects of the use of stimulants; in kaart te brengen.
The primary objective of the current study is to investigate whether self-disgust is heightened in patients with AN. If this indeed is the case, this would provide important leads to improve existing treatment options for AN.
This cohort study aims to explain why some children develop well and others fail to thrive in society. To this purpose, we examine how neurocognitive development mediates the association between developmental changes in biological, child-related and…
Primary: - Examine longitudinal developmental trajectories of structural and functional brain metrics in relation to genetic, clinical, psychological, environmental, and cognitive information in familial high-risk offspring and control children (…
The primary objective of this study is to derive and externally validate a prognostic screening instrument to predict individual risk to follow an adverse PTSD symptom trajectory over the course of one year following trauma based on self-report…
The overall goal of the PRISM programme of research is to develop a quantitative, transdiagnostic, neurobiological approach to the understanding of neuropsychiatric disorders in order to accelerate the discovery and development of better treatments…
This study aims to add the new ASL MRI sequence to the scanning protocol of the Centrum voor Ouderengeneeskunde Amsterdam (COGA) study (METC number 2017.148), to study the BBB integrity of the subjects included in the COGA study.
In this study we aim to further characterize E/I balance (at different translational levels), and its relation to metabolic- and immune processes, clinical profiles, behavior and cognition
The main objective of this project is to study the prevalence of autoantibodies against the NMDA-r, AMPA-r, GABAB-r and VGKC-complex (LGI-1 and Caspr-2) in patients with an early onset psychotic disorder. Patients suffering from stable but also…
The primary objective of the SCIENCe project is to establish a prospective cohort of patients with subjective complaints, to study the earliest brain changes ultimately leading to cognitive decline and dementia due to AD. Specific research questions…