61 results
The first objective is measuring striatal D2 receptor binding before and after dopamine depletion with AMPT in the UHR population compared to healthy controls, and investigate whether dopaminergic dysregulation is present prior to transition to…
In this study we aim to assess dopamine synthesis in healthy subjects with isolated hallucinations using 18F-DOPA PET.
The aim of the project is to apply neuro-economics in order to elucidate mechanisms underlying disturbed social cognition in paranoid delusions at the level of the cognitive mechanisms. This will be done in patients with lifetime presence of non-…
Main objectives: (1) To identify genetic, environmental and clinical determinants of psychosis vulnerability and onset. (2) To assess neural systems and behavioural substrates mediating gene environment interactions. (3) To test for gene-…
Primary Objective: 1. Are the effects of conscious and unconscious priming effects on selfagency different in schizophrenia as compared to health?2. What are the functional and structural neural substrates underlying conscious and unconscious…
To test the following hypotheses:1. The baseline [123I]IBZM binding potential ([123I]IBZM-BP) in the ventral striatum is smaller in patients with SAHI than in healthy subjects, due to increased baseline activity of the mesolimbic dopamine system. 2…
Objective: (1) to develop and apply methods for the detailed assessment of candidate environmental exposures, at both individual and area levels, by using an optimum, family-based, case-control design, in a diverse range of settings across Europe. (…
The aim of this study is to investigate the differences and similarities in AVH in healthy subjects and in patients with different psychiatric disorders. In addition, the underlying biological mechanisms of AVH will be studied in detail:1)…
The aim of this study is to examine three types of motor learning reflecting the function of different brain regions: brain stem, cerebellum and the basal ganglia. Besides the basal ganglia which are one region with a high presence of dopaminergic…
Studie A:1. To study the psychometric properties of the Dutch version of the PIQ in a non-clinical and clinical sample.2. to study the relationship of persecutory delusions and aggression in a non-clinical and clinical sample.Studie B:3. To test the…
Aim 1: To examine the determinants of aggressive behavior in patients with a psychotic disorder. The main focus is on affective responses to psychotic symptoms which can be predictable for aggressive behavior in these patients. Aim 2: In addition,…
1. Are there differences in the trajectories of brain volume change with age between patients and healthy individuals (longitudinal design)?2. What are the effects of age on white matter integrity in healthy subjects and do patients show…
1)To determine whether subjects at ultra high risk to develop schizophrenia display hepatic insulin resistance as compared to healthy controls matched for age, sex, BMI, ethnicity, visceral and subcutaneous fat mass.2)To determine whether…
With this study we want to identify the common aetiology and neurobiology of EFD, by employing pharmacological and genetic imaging in three neuropsychiatric disorders. We want to identify an underlying functional and structural model for EFD,…
This study will assess both implicit and explicit effect expectancies associated with marijuana in individuals with psychotic disorder. We will determine whether such expectancies are different from those of people in the general population. We will…
This study aims to identify the genes that moderate the influence of cannabis use on the symptoms of schizophrenia in order to illuminate the mechanisms of action of cannabis and shed new light on the aetiology of schizophrenia.
To perform a genetic study of left-handedness and language lateralization as endophenotypes of schizophrenia. The study will make use of 30 extended multigenerational pedigrees with multiple left-handers from Urk, an isolated population in The…
Do patients, suffering from schizophrenia, who have (clinically) a flattening of affect, also have abnormalities in pain perception and expression ( i.e. a higher threshold for pain perception and tolerance).
In the current project we will investigate multiple risk factors and their interaction in a single study design, aiming to identify different profiles associated with social withdrawal behaviour in an Ultrahigh Risk and First Episode Psychosis…
The main objective of the study is to investigate the muscarinic cholinergic system as a biological substrate for cognitive dysfunction in first episode psychosis patients, i.e. at onset of illness. We seek to assess whether deficits in M1…