358 results
This study has been transitioned to CTIS with ID 2024-512736-29-00 check the CTIS register for the current data. Primary Objective1. To evaluate the safety and tolerability of long-term dosing of losmapimod tablets in subjects with FSHD1Secondary…
The primary objectives of this project are to assess the mtDNA mutation load in carriers of a mtDNA mutation and identify patients and/or mutations with no/low mtDNA mutation load in mesoangioblasts. Secondary objectives aim at determining the…
The phase I/IIa trial will consist of an intra-arterial injection (via catheter in femoral artery) of autologous MABs in the left lower leg of 5 m.3243A>G patients. The primary objective is assessing safety of administration of autologous…
Phase 1. Primary Objective: To evaluate the feasibility of the study procedures to measure breathing-task related cerebral activity using fMRI and respiratory (electro)physiological measures of breathing. Phase 2. Primary Objective: To identify…
Primary Objective: There are three primary objectives in this study. 1. To investigate the neuromuscular involvement of RYR1 related MH and rhabdomyolysis. 2. To investigate the immunological changes in subjects with RYR1 related MH and…
This study has been transitioned to CTIS with ID 2024-518269-92-00 check the CTIS register for the current data. The objective of the study is to gather more information about the long-term effect of enzyme therapy in patients with Pompe disease…
The aim of our study is to establish the long-term course of (recovery of) respiratory muscle strength and exercise capacity in patients who have received * 48 hours of mechanical ventilation and are discharged home.
The main objective of this study is to research whether implementation of a focused personalized problem-oriented coaching intervention (coach2move strategy) is more effective to improve physical activity, mobility and health status in community-…
The effects of quark ingestion with or without prior exercise on muscle protein synthesis rates in young and old men.
To compare quantitative muscle MRI measurements between DMD and BMD patients and healthy controls. Comparisons will be made cross-sectionally and longitudinally. In addition, dystrophin expression in two different leg muscles will be studied in BMD…
Primary objective: To evaluate if DTI is able to predict the convalescence period and detect (residual) injury to the hamstrings.
The primary objective is to quantify the postprandial area under the curve (iAUC), the maximal level (Cmax) and the time profile (Tmax) of blood amino acids after ingestion of milk protein, micellar casein, pea protein, and a milk protein-pea…
Primary objective:* To establish the effects of givinostat versus placebo administered chronically over 18 months to slow disease progression in ambulant DMD subjects.Secondary objectives:* To assess the safety and tolerability of givinostat versus…
1. Our finding that measuring MEP at 12 weeks gestation could be an important marker for normal or abnormal delivery which needs to be confirmed in a separate study. 2. To measure the echogenicity of the uterus (myometrium), cervix and vastus…
The primary objective of the present study is to establish the histological effects of givinostat versus placebo administered over 12 months. The secondary objectives of this study are the following: - To establish the macroscopic muscle effects of…
The objectives of the study are:* To evaluate the safety and tolerability of zilucoplan in subjects with IMNM* To evaluate the efficacy of zilucoplan in subjects with IMNM
To investigate lingual articulation and coarticulation as well as variability of speech in children with DMD, as compared to their healthy peers. This information will lead to a better understanding of how speech is impacted by DMD and will…
Effects of NMES on physical function and skeletal muscle mass
1. Is passive movement therapy an effective intervention on the severity of paratonia in comparison with usual care without passive movement therapy?2. Is passive movement therapy an effective intervention for improvement of daily care?
The primary goal is to evaluate the difference between diaphragm tissue characteristics and movement in extubated COVID-ICU patients after >72 hours of invasive mechanical ventilation compared to other ICU-patients and healthy controls.…