19 results
This project aims to determine the validity of a home-based continuous bradykinesia assessment using free typing behaviour analysis. Secondarily, we aim to capture the presence of sequence effect in Parkinson's Disease patients using a computer…
Objective: The primary objective of this study is to investigate whether pain experience decreases or increases when cognitive functions decline in patients with Parkinson's disease. Furthermore will be investigated whether this is influenced…
The primary objective of this study is to confirm early and subtle MRI changes in PD patients which distinguish them from the healthy population and to create a diagnostic tool for neurologists based on these differences. Secondary objectives are to…
The main study objective is to determine the prevalence of tremor in patients with neuropathy and describe the tremor characteristics.Secondary study objectives are: - To evaluate the functional disability and quality of life in patients with…
Lu AF28996 is an orally administered investigational compound of a potent, long-acting dopamine agonist, Lu AA40326, currently under development by H. Lundbeck A/S for the treatment of Parkinson*s disease (PD). Primary Objective:to investigate the…
The aim of the study is to investigate the effect of an intensive high frequent parental coaching intervention on communicative abilities in patients with AS. Patients with AS who receive standard care, will serve as controls. Parents/caretakers in…
The primary objective of this study is to explore the potential efficacy of the Holocue application for alleviating FOG episodes through on-demand cue activation. In order to achieve this, walking data obtained from the Hololens will first be…
Our primary objectives are to study: 1) differences in the brain*s sensitivity to the effects of light on emotional processing in people with PD and people with depressive symptoms compared with healthy controls 2) whether different spectrum of…
To develop and validate a probabilistic subcortical atlas of a PD population using 7Tesla MRI, and to validate this atlas for use on 3T MRI data.
The goal of this research is to assess whether cognitive effort (mental arithmetic) or fear (threat of shock) have a similar or different effect on Parkinson*s tremor and noradrenergic activity. In the following, obtained knowledge and empirical…
The primary objective of this study is:* To investigate whether a two-weeks intervention with cerebellar anodal tDCS could improve ataxia severity in SCA3 patients compared to sham stimulation.Secondary objectives of this study are:* To investigate…
Primary objectivesPart 1:* To evaluate the safety and tolerability of escalating single oral doses of CAD-1883 in healthy male subjects.Part 2:* To determine the effect of food on the PK profile of a single oral dose of CAD-1883 in healthy female…
1. To study the differential effectiveness of three cueing modalities on gait parameters, gait stability, and interlimb coordination in people with Parkinson's disease 2. To study the differences between self-selected and a 10% increased cueing…
We aim to study the cost-effectiveness of specialized nursing care provided by a Parkinson Disease Nurse Specialist (PDNS) as compared to no PDNS care for patients with Parkinson's disease in all disease stages.We will also perform a subgroup…
To investigate the timing and coordination of speech articulation of PD patients. This information will lead to a better understanding of dysarthria and will ultimately aid speech therapy.
Augmented Reality cues to reduce Freezing of Gait during turning in persons with Parkinson*s disease
The primary objective of this study is to investigate the effect of visual turning-cues presented in augmented reality on the severity of freezing of gait evoked during turning in patients with Parkinson*s disease. This effect is compared to that of…
The primary objective is to examine the contribution of arm swing to the onset and continuation of locomotion in healthy individuals and PD patients and to study activity in its underlying functional brain networks. Secondary objectives are to…
* To determine the relationship between phenotypic and genetic characteristics of GBA-PD patients. Phenotypic characteristics will be obtained by patient dossier review. Genetic characteristics comprise of the GBA1 gene and a panel of SNPs,…
To identify the cerebral mechanisms underlying clinical disease progression in PD. The current proposal aims to further specify: (1) differences in motor and limbic activity between patients and controls; (2) the effect of dopamine on motor and…