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Mechanisms of disability in MS patients with long disease duration

*To examine the (longitudinal) association between long term clinical outcomes in MS and pathology occurring in brain grey matter, spinal cord grey matter and brain lesion load.

A 3-year, multi-center study to evaluate optical coherencetomography as an outcome measure in patients with multiple sclerosis

Primary objective: To evaluate change in RNFL thickness in RRMS patients followed for up to 36 monthscompared to a group of reference subjects (without neurologic or ophthalmic disease) todetermine whether the technology is sufficiently sensitive to…

The contribution of the central nervous system to fatigue in patients suffering from MS

In the proposed experiments we intend to investigate both central and peripheral aspects of fatigue in MS-patients using a combination of simultaneously applied techniques; twitch-superimposition, electromyographic (EMG) and force recordings and…

Atypical parkinsonism: Early diagnosis with quantitative MRI

Primary Objective: To investigate whether a quantitative MRI protocol can detect the difference between atypical parkinsonism and patients with Parkinson*s disease, in an early phase of the diseases when the clinical diagnosis for either is not yet…

Prevalence of Lyme neuroborreliosis among patients with painful radiculopathy visiting a teaching hospital in a Lyme endemic region

Primary objective:The study objective is to assess whether there is a difference in prevalence of positive Lyme serology in patients with painful radiculopathy with nerve root compression versus patients with painful radiculopathy without nerve root…

Neural processing of olfactory stimuli in response to smell loss

The primary objective of this study is to investigate the difference in brain activation in response to odour stimulation between patients and controls. The secondary objective is to investigate the relationship between smell ability and brain…

Advanced MRI techniques and biomarkers to substitute gadolinium enhanced MRI for the detection of disease activity in multiple sclerosis.

1) To determine whether advanced MRI techniques can detect active inflammatory Gd enhancing lesions. 2) To determine whether blood biomarkers are associated with the presence of enhancing brain lesions in MS. 3) To determine whether advanced MRI…

The MS-CEBA study: determining Cognitive, Energetic, Behavioural and Affective (CEBA) profiles in Multiple Sclerosis

The aim of the present study is identifying CEBA profiles in pwMS and subsequently developing a feasible screening tool allowing quick identification of CEBA profile and subjective burden of pwMS in clinical practice, providing a suitable indication…

Optimisation of research protocols for respiratory challenges with the RespirAct (RA-MR)TM in healthy volunteers

Optimisation of MRI research protocols including respiratory challenges with the RespirActTM.

The evaluation of the cerebellar symptoms in patients with opsoclonus myoclonus syndrome diagnosed and treated at the Sophia*s Children*s hospital

The objective of the study is to evaluate the cerebellar symptoms in children with OMS diagnosed and treated at the Sophia Children*s Hospital.

Test-Retest of MR Fingerprinting technology for improved visualization and quantification of tissue and organs in healthy volunteers and brain tumor patients

To optimise, test and evaluate new and modified MRI sequences and technology under a test-retest scheme. To validate new sequences in patients in order to reduce MRI protocols in the future.