13 results
*To examine the (longitudinal) association between long term clinical outcomes in MS and pathology occurring in brain grey matter, spinal cord grey matter and brain lesion load.
In the proposed experiments we intend to investigate both central and peripheral aspects of fatigue in MS-patients using a combination of simultaneously applied techniques; twitch-superimposition, electromyographic (EMG) and force recordings and…
Primary objective: To evaluate change in RNFL thickness in RRMS patients followed for up to 36 monthscompared to a group of reference subjects (without neurologic or ophthalmic disease) todetermine whether the technology is sufficiently sensitive to…
Optimisation of MRI research protocols including respiratory challenges with the RespirActTM.
The aim of the present study is identifying CEBA profiles in pwMS and subsequently developing a feasible screening instrument allowing quick identification of CEBA profile and subjective burden of pwMS in clinical practice, providing a suitable…
Primary Objective: To investigate whether a quantitative MRI protocol can detect the difference between atypical parkinsonism and patients with Parkinson*s disease, in an early phase of the diseases when the clinical diagnosis for either is not yet…
Primary Objective: To compare the efficacy of MEDI-551 versus placebo in reducing the risk of an NMO/NMOSD attack in subjects with NMO/NMOSD.Secondary Objectives:1. To compare the efficacy of MEDI-551 versus placebo on the reduction of EDSS…
To optimise, test and evaluate new and modified MRI sequences and technology under a test-retest scheme. To validate new sequences in patients in order to reduce MRI protocols in the future.
The objective of the study is to evaluate the cerebellar symptoms in children with OMS diagnosed and treated at the Sophia Children*s Hospital.
The primary objective of this study is to investigate the difference in brain activation in response to odour stimulation between patients and controls. The secondary objective is to investigate the relationship between smell ability and brain…
Primary objective:The study objective is to assess whether there is a difference in prevalence of positive Lyme serology in patients with painful radiculopathy with nerve root compression versus patients with painful radiculopathy without nerve root…
1) To determine whether advanced MRI techniques can detect active inflammatory Gd enhancing lesions. 2) To determine whether blood biomarkers are associated with the presence of enhancing brain lesions in MS. 3) To determine whether advanced MRI…
Primary objectives:• To characterize the central inflammatory response to IV LPS by measuring biomarkers in CSF• To characterize the systemic inflammatory response to IV LPS by measuring biomarkers in blood • Characterize CSF/Blood ratios for each…