23 results
The aim of this study is to investigate the effects of DMF (Tecfidera) on the association between fatigue and fatigability measures in pwRRMS starting with DMF medication.
*To examine the (longitudinal) association between long term clinical outcomes in MS and pathology occurring in brain grey matter, spinal cord grey matter and brain lesion load.
1). Evaluate the expression of the genes encoding the enzymes that modify histones and DNA during monocyte differentiation in MS.2). Consequences of monocyte dysfunction for migration and cytokine/chemokine production.
Primary objective:* To analyze the association between single nucleotide polymorphisms (SNP) markers and treatment response. Treatment response is based on the Expanded Disability Status Scale (EDSS) progression and relapse outcomes over the first 2…
Primary objective: To evaluate change in RNFL thickness in RRMS patients followed for up to 36 monthscompared to a group of reference subjects (without neurologic or ophthalmic disease) todetermine whether the technology is sufficiently sensitive to…
To quantify changes in range of motion (RoM) and muscle strain of the shoulder in hemi paretic stroke survivors compared to healthy controls in order to identify potential contracted or paretic muscles.
The overall objective of this trial is to provide additional data on the factors influencing IFN-beta response.Primary· To analyze the association between single nucleotide polymorphisms (SNP) markers and Rebif and Copaxone treatment response.…
The objective of the study is to estimate the prevalence of anti-JCV antibodies in MS patients,including the following criteria:* Age* Gender* Race* Country of birth and the duration of residence* Current country of residence and the duration of…
In the proposed experiments we intend to investigate both central and peripheral aspects of fatigue in MS-patients using a combination of simultaneously applied techniques; twitch-superimposition, electromyographic (EMG) and force recordings and…
The NEURONED-MS cohort study aims to facilitate prospective observational research in the field of multiple sclerosis (MS). This cohort will serve as the central part of several projects that will be organized to address various issues including:1.…
Primary Objective: To investigate whether a quantitative MRI protocol can detect the difference between atypical parkinsonism and patients with Parkinson*s disease, in an early phase of the diseases when the clinical diagnosis for either is not yet…
Primary objective:The study objective is to assess whether there is a difference in prevalence of positive Lyme serology in patients with painful radiculopathy with nerve root compression versus patients with painful radiculopathy without nerve root…
1. To measure clinical outcome of patients with an autoimmune encephalitis longitudinally.2. To evaluate existing PROMS, developed for other (neurological) disease, for patients with an autoimmune encephalitis.3. To develop and validate disease-…
The primary objective of this study is to investigate the difference in brain activation in response to odour stimulation between patients and controls. The secondary objective is to investigate the relationship between smell ability and brain…
Primary objectives:• To characterize the central inflammatory response to IV LPS by measuring biomarkers in CSF• To characterize the systemic inflammatory response to IV LPS by measuring biomarkers in blood • Characterize CSF/Blood ratios for each…
Recent neuroimaging research identified different pathways of how distraction is processed in WM, showing involvement of the lateral prefrontal cortex and striatum (15,21,22). It has been described that if a combined demand of WM and distraction is…
1) To determine whether advanced MRI techniques can detect active inflammatory Gd enhancing lesions. 2) To determine whether blood biomarkers are associated with the presence of enhancing brain lesions in MS. 3) To determine whether advanced MRI…
The aim of the present study is identifying CEBA profiles in pwMS and subsequently developing a feasible screening tool allowing quick identification of CEBA profile and subjective burden of pwMS in clinical practice, providing a suitable indication…
Optimisation of MRI research protocols including respiratory challenges with the RespirActTM.
The objective of the study is to evaluate the cerebellar symptoms in children with OMS diagnosed and treated at the Sophia Children*s Hospital.