117 results
To assess the association between baseline blood pressure and change in neurocognitive functioning after four years, and to assess whether baseline MRI phenotypes are predictive for changes in neurocognitive functioning after four years in the DANTE…
The main objective of this study is to assess the effect of an acute cardiovascular event on the local and the systemic inflammatory state in humans with AMI as well as the reversibility of these effects after 3 months.
Explore difference in perforating artery pulsatility index between two patients groups with small vessel disease (history of lacunar infarct and deeply located haemorrhage) and healthy controls.
The overall aims of the proposed project are 1) to establish biomarkers for identification of the underlying vascular disease in patients with ICH and 2) to characterize whether disruption of the blood-brain barrier, a key factor in secondary brain…
To detect ophthalmic differences between patients and controles. To detect (early) changes in the retina in (pre)symptomatic RVCL disease carriers, in order to find a *biomarker* for disease stage and progression.
Main study objective of this study is:To evaluate whether the 320-detector volumetric CT technology can replace carotid duplex scanning and TEE in the diagnostic workup in TIA/IS patients. Specific aims of this main study objective are:1. To assess…
Primary Objective: To assess which measures of microvascular function on 7T MRI are affected in patients with CADASIL, relative to controls.
Area of interest (study setting): Specific aims:Transient triggers and chronic riskfactors (case-crossover and casecontrol)(1) To investigate frequency and strength of association between transient physical andpsychological triggers and early-onset…
To assess whether temporary discontinuation of antihypertensive therapy in mildly cognitively impaired older patients on antihypertensive treatment improves cognitive and psychological functioning.
Primary: to study the frequency and characteristics of fatigue and cognitive disorders after minor stroke. Secondary: to gain more insight in the aetiology of post-stroke fatigue and evaluate the impact of post-stroke fatigue on personal and social…
The aim of this study is to compare the integrity of the corticospinal tract and cortical reorganization of shoulder girdle muscle representations in chronic stroke patients with and without GHS as well as healthy controls.
To further investigate the pathogenesis of DCI and its relation to gender, decreased fibrinolysis, increased coagulation, and hormonal factors in order to eventually pave the way for new treatment options.
To determine the incidence of hypopituitarism in patients after SAHTo identify neurological parameters that predict hypopituitarism after SAHTo determine the value of a Ghrelin test shortly after SAH, to identify subjects with GHD.To determine the…
1) to investigate cognitive functioning in lacunar infarct patients with and without periventricular white matter lesions; 2) to identify predictors for cognitive dysfunction in lacunar infarct patients.
Primary objective: to assess cortical activity post stroke in a repetitive way to determine cortical involvement in dedicated motor tasks and to relate cortical activity to clinical outcome prospectively after stroke. Secondary objective: to assess…
To explore the underlying mechanisms explaining walking ability and walking activity.
To investigate the risk of deeath and incident (cardio)vascular disease in patients with a TIA or stroke aged 18-50 yearsTo investigate the riks of cognitive impairment and (vascular) dementia in patients with a TIA or stroke aged 18-50 yearsTo…
1) to investigate whether hypertensive patients with WMLs decline more strongly in cognitive function than hypertensive patients without WMLs in a 4-year time period. 2) to identify predictors for cognitive dysfunction in hypertension/SVD patients.
To establish evidence on the effectiveness of long term rhythm observation using an implantable loop recorder for detecting atrial fibrillation in patients with cryptogenic stroke.
Measuring the thickness of the microvascular glycocalyx, and make a comparement between lacunar stroke patients and healthy controls.We also compare glycocalyx between patients with and without concomitant silent signs of cSVD on brain MRI.