27 results
Sample collection for in vitro research
The primary objective of this cohort study is to determine the prevalence of simple and progressed NAFLD in subjects at risk followed by the general practitioner The secondary objectives are:1. To study the factors linked to the development of…
The aim of this research proposal is to examine the effect of different ISIs on mTc-MEPs.Primary research question: What is the effect of different interstimulus intervals (ISIs) on mTc-MEP thresholds, peak-to-peak amplitudes, and area under the…
1A) To implement a screening-protocol for HIV related co-morbidities and their risk factors, based on multidisciplinary expert consultation, in a large HIV outpatient clinic and among an HIV-uninfected control group.1B) To assess the prevalence and…
1. To study the possibility to detect gynaecological malignancies and endometriosis in vaginal self-swabs, Pap smears and blood of women with gynaecological cancer or endometriosis, using MeD-seq and MeD-scan assays, in order to develop…
The aim of this project is to evaluate the clinical value of biomarkers in adult patients with pulmonary hypertension, in particular:1) To quantify biomarkers of neurohormonal activity as NTproBNP, endotheline-1 and of immunological activity as CRP…
The primary objective of this study is to build a predictive model in which we can identify which (pheno) type of ALS patients has the most benefit from NIV in improving or maintaining quality of life.
The objective of the study is to establish a data infrastructure to investigate the degree in which current and previous generations of young-old are characterised by healthy and successful ageing.
1) To collect information on patient characteristics, short- and long-term clinical and patient-reported outcomes; and 2) to create an infrastructure for efficient, fast, and pragmatic randomized evaluation of new interventions.
Objective 1: To improve the understanding of the dynamic phenotypic spectrum and the disease mechanisms of HD by:a. collecting natural history data covering the cognitive, behavioral and motor domains permitting estimates of rates of progression in…
The purpose of this study is to evaluate the feasibility and efficiency of transducing freshly obtained CD34+ HSC from either mobilized peripheral blood or bone marrow of healthy donors using lentiviral SIN vectors encoding codon-optimized human…
The main study objectives include to:a. Use clinical and biological data to estimate the mean rates of change and the variability around the mean of clinical, digital, imaging, biological and genetic outcomes in study participants…
First, to establish the yield of the currently propagated pancreatic cyst surveillance program, and second, to identify possible alternative surveillance strategies, which might be more (cost) effective.
1. To identify the perceived barriers and facilitators for initiating and maintaining a healthy lifestyle in people with both DM2 and a low SEP. 2. To co-create a digital, personalised CBT lifestyle tool together with end users (people with DM2) to…
The study will help us to determine 1. the necessary type of (combined) examinations and 2. the sample size that is essential to evaluate (future) genetic therapy in Usher syndrome type 2 and USH2A associated nsRP.
Given the above mentioned gaps in knowledge, the aim of this project is to1) Describe the midterm and long-term outcomes of (primary and revision) total hip, total knee and shoulder replacement surgery in terms of health status as a whole,…
Primary objective1. The primary aim of the study is to answer the question whether specification of a positive direct antiglobulin test and/or red blood cell autoantibody specification is correlated with the clinical course in patients with AIHA.…
Main objective is to determine whether nerve excitability can detect drug-induced effects of Riluzole in yet treatment- naïve patients with ALS. Secondary objectives are to determine the correlation between the Riluzole plasma concentration levels…
To compare the degree of osteoarthritis in the knee after 10 years, in patients with non-obstructive meniscal tear, between meniscal surgery and exercise therapy treatment.
Whole genome comparison between microorganisms cultured from PJI and those cultured from preoperative swabs of the patients’ microbiome, to determine the origin of the infection.