234 results
The primary objective is to assess neuropsychological function in X-ALD patients without active cerebral demyelinating disease. Data of minors will be compared to matched healthy controls. Data of adults will be compared to reference values. The…
Study i)Select the most valid and feasible accelerometer for measuring habitual physical activity in children with a mitochondrial disorderStudy ii)Measure the test-retest reliability of this instrument
1) To perform gene mutation analysis in family members of patients carrying a proven mutation in the candidate gene.2) To determine the clinical, biochemical and radiological characteristics of carriers of a mutation in the candidate gene.3) To…
A fundamental question in the current research proposal concerns how changes in cognitive and social-emotional behavior are related to functional and anatomical brain development. The current proposal has the objective to (a) understand the neural…
The aim of this study is to validate known, and identify novel allelic variants which may play a role in the risk of cisplatin-induced ototoxicity in a substantial international cohort of children diagnosed with cancer.
Original study:The goal of this study is to have a theoretically based understanding of how sub processes of self-concept development emerge in relation to each other. The primary objective is to test a neuroscientific model of self-concept…
In Phase 1 of the project, a systematic approach will be used to identify which factors add to the prediction of children*s clinical risk status. First, we will determine how well multiple assessments of behavioral problems (opposition, aggression,…
The primary objective is to study if quantitative (3- and 7-Tesla) MRI protocols (MRI perfusion, diffusion tensor imaging (DTI), and chemical shift imaging (CSI)) are able to detect phenotype conversion earlier than conventional MRI. Results will be…
Evaluate the effect of menarche and menstrual cycle on the QTc interval among girls with genetically confirmed mutations causing LQTS type 1 (LQT1) and type 2 (LQT2).
First objective: gain insight in the coordination of trunk, head and arm during functional tasks in healthy children and compare this with the coordination in children with DMD, SMA and CP. Second objective: investigate if newly developed supportive…
Primary objective1) To study the frequency of mutations in this gene in patients with central hypothyroidism and their first- and second-degree relativesSecondary objective: 2) To determine the clinical, biochemical and radiological consequences of…
Primary Objective: To further optimize the IPMDSSecondary Objective(s): To determine in which age-groups the items within the IPMDS are appropriate To determine whether the IPMDS can assessed reliably by research nurses, students and physician…
In this study we would like to find new biomarkers in BOS after haematopoietic stem cell transplantation (HSCT), that may lead to earlier identification of BOS than a lung function decline.
To obtain a comprehensive overview of long-term (*5 years after burn injury) consequences after burn injuries, both in all patients admitted to burn centre admissions and in a subgroup of patients who suffered from more extensive burns.
To study feasibility, reliability and validity of a specific set of outcome measures in children with mitochondrial myopathy.
The aim of this proposal is threefold: (i) test a neuroscientific model of prosocial development by relating neuroscience discoveries to changes in several dimensions of prosocial development in a comprehensive study including children, adolescents…
The aim of the study is to strengthen the basis for a new application of pupillometry (i.e., the measurement of pupil dilation) within the field of Audiology. An innovative method to quantify listening effort (pupillometry) will be further developed…
Objective of this study is to determine if Optical Coherence Tomography (OCT) measurements are a reliable measure of the severity of neurological impairment in patients with X-ALD and ZSD and therefore if OCT is an acceptable "surrogate"…
To evaluate the prevalence of femoral head pathology in patients with MPS III.
Main objective: To quantify mumps transmission parameters in exposed individuals, comparing symptomatic and asymptomatic cases, to understand and model ongoing transmission; Secondary: to assess cellular immuunresponses in mumps exposed infected and…