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Natural course, effects of enzyme therapy and health economic aspects in patients with mucopolysaccharidosis type I, II and VI. Long-term folloe-up of untreated patients and patients receiving commercially available Aldurazyme, Elaprase and Naglazyme.

the objective of the current study is to evaluate the safety and efficacy of enzyme therapy in the Dutch population of patients with MPS I, II and VI; to compare this to the natural course of these diseases; to make an inventory of the direct and…

Comparing accuracy, patient experiences and costs of lower gastrointestinal endoscopy between nurse and physician endoscopists; a prospective cohort study.

To compare accuracy, patient experience and costs of lower gastrointestinal endoscopy (sigmoidoscopy and colonoscopy) between nurse and physician endoscopists.

Evaluation of the potential of Real-Time 3-Dimensional echocardiography in the assessment of right ventricular function in patients with congenital heart disease: comparison of RT-3D echo with MRI.

The aim of this study is assessment of right ventricular function: a comparison between MRI and real-time 3-D echocardiography (RT 3-D echo). We have the following research questions: 1) Is assessment of right ventricular (RV) function with RT 3-D…

Does borderzone contrast enhancement on intraoperative MRI during high grade glioma resection correlate with residual tumor?

This study wants to evaluate on intraoperative MRI whether contrast enhancement at the borders of the resection cavity correlates with tumor tissue, and whether no contrast enhancement correlates with the absence of tumor tissue. To differentiate…

Validation of a repeated cardiopulmonary exercise test for the assessment of physical impairment in chronic fatigue syndrome.

We need objective and validated tests for the assessment of the severity of impairment in CFS/ME patients. In 2 areas these tests will be essential: for studies of the effect of interventions and for the assessment of disability.Hardly any research…

Inflammation, excacerbation of heart failure, and ventricular tachyarrhythmias in stable heart failure patients with implantable cardioverter-defibrillator.

The aim of the present study is to evaluate whether there is an association between biomarkers (hs-CRP and BNP)

Optimization of MRI protocols in patients.

The aim is the optimisation of MRI-sequences in patients for clinical and scientific purposes.

Assessment of Cognitions Associated with Post-Traumatic Stress Disorder

The aim of the present study is to investigate: 1) the relationships among different cognitive measures, and 2) the specific relationship of these measures with PTSD symptoms.

Development of a general practice-based diagnostic asthma-risk index in young children: Reaping the benefits from an ongoing cohort study.

To construct a clinical asthma-risk index for 1- to 3 year old children who visit the GP with asthma related complaints. In addition, the effectiveness of two broad treatment strategies (aggressive versus non-aggressive) in children with the same…

Peripheral Neuropathy Outcome Measures Standardisation Study

The ulitmate goal of the current study will be the presentation of a specific minimum core set of outcome measures to be used in future clinical and follow-up studies in patients with autoimmune mediated polyneuropathies.

Burden of Obstructive Lung Disease

The BOLD initiative is designed to provide a means to collect high-quality, country-specific data on the prevalence and social and economic burden of chronic obstructive pulmonary disease (COPD) using strictly standardized, tested methods. BOLD data…

The clinical value of measuring gastric emptying in children with a severe generalized cerebral palsy

The objective of the study is to determine what the clinical value is of measuring GE of liquids in 50 SMID children. The primary study parameter is how often DGE of liquids occurs in this study group. Secondary study parameters include…

The latency of the P300 peak (an outcome of an electrofysiological measurement) as an objective measure of auditory processing

The aim of the study is to archive an objective measure for auditory processing disorders, using the P300 measurement, an auditory event related potential. This to be able to discriminate between children with and without auditory processing…

thrombin generation in plasma, the predictive value of endogenous thrombin generation (ETG)in relation to hypercoagulability and bleedingrisk

Assessing hereditary and aquired determinants of ETP. Evaluating the use of ETP as predictive stand alone test for recurrent DVT and bleeding complications due to anticoagulation therapy in comparisson with the current prediction methods.

Evaluation of in vitro assays (lymphocyte proliferation assays, cytokine production assays and/or T spot TBtm and/or Quantiferon-TB Gold) during follow-up of individuals with recent Mantoux skin test conversion, or (latent or clinically active) Tuberculosis.

Hypothesis:- The height of the result of the MTB-specific assays is directly related to the number of MTB bacilli present. As a result, effective treatment of persons with LTBI will cause a decrease of the quantitative test result and finally a…

Reducing the prescription of antibiotics in newborn infants suspected for having an early onset sepsis.

Our preliminary data shows that the prescription rate of antibiotics for suspected EOS versus blood culture proven EOS was high. We aim to develop a new diagnostic model to reduce unnecessary antibiotic treatment which can be tested in the near…

CArdiac magnetic resonance perfusioN imaging for SELection of patients for additional invasive evaluation after CT coronary angiography (CANSEL)

To validate MR myocardial perfusion by first pass magnetic resonance with adenosine stress in patients with suspected coronary artery stenosis as identified by CT-CA, using FFR as the reverence method.

Crossvalidation of the MMPI-2 RC scales in a Dutch psychiatric sample.

Validity of the Dutch MMPI-2 RC-scales.

Transjugular Intrahepatic Portosystemic Shunt (TIPS): accuracy of MR Flow mapping in the detection of shunt abnormalities.

Primary Objective:Validate the accuracy of:· MR Flow mapping in measuring PPG in patients with GoreTex®-covered TIPS as compared to the gold standard, portography.· MRA for establishing TIPS patency as compared to Doppler US and using invasive…

Repetitive nerve stimulation in proximal muscles: technical implementation

Which position of the person and which positions of the electrodes on the shoulder create the best recorded and best reproducible muscle amplitude?