135 results
The primary objective of this study will be to evaluate the cardiac adaptation due to hemodynamic changes in monochorionic twin pregnancies complicated by TTTS and sIUGR, by evaluating the size and the growth pattern of the pulmonary artery and the…
• To assess the prevalence of short stature, in combination with an aberrant IGF-1 in combination with IGF-BP3 in the entire cohort of childhood cancer survivors and the therapy related risk factors.• To assess the distribution of IGF-1 and IGF-BP3…
The main objective of the study is to investigate the muscarinic cholinergic system as a biological substrate for cognitive dysfunction in first episode psychosis patients, i.e. at onset of illness. We seek to assess whether deficits in M1…
This study had two objectives:1. which factors determine outcome of treatment of children with functional childhood constipation referred to the outpatient clinic of multidisciplinary treatment clinics in the Netherlands;2. which factors can be…
To investigate the effect of tourniquet application on the coagulation system in patients undergoing a knee arthroscopy. A finding of more prominent activation of the coagulation system with tourniquet use than with non-use will create an important…
1. Determine the relationship between periodontitis and HIV-related immune activation and hypercoagulability.2. Explore the role of oral microbiota as effect modificator of the relationship between periodontitis and immune activation in HIV-infected…
To investigate whether twice daily local (calf muscle) NMES attenuates muscle loss during 2 weeks of unilateral ankle immobilization due to an ankle fracture.
The purpose of this study is to test whether perceptual expectations modulate V1 activity consistent with *hypo-priors* in autistic individuals.
To test the suitability of OCT for in vivo imaging of the vascularisation and surrounding tissue of burn wounds and scars.
To obtain human fibroblasts from extreme dyslipidemia patients or patients with premature atherosclerosis to study cholesterol metabolism.
Objective:The aim of this project is to apply motor-cognitive-mental elements together for psychiatric diagnosis, treatment, and prevention. We will examine and quantify the diagnostic value of motor-cognitive-mental elements in predicting (a)…
The objective of the study is to map in a standardized way the phenotype of carriers with known LHON mutations. We want to study the natural course of persons with LHON mutations by examining patients several times. Further, we want to study a…
Primary Objectives: 1. To assess the values of ARI and APDR in NICM patients. 2. To assess the three-dimensional heterogeneity of ARI and APDR in NICM patients.3. To compare 1. and 2. with the same data collected from non-NICM patients.4. To…
Primary Objective: To objectively and subjectively investigate sleep and fatigue among Dutch and British offshore workers and their influence on health safety and performance.Secondary Objective(s): • To examine the course of cortisol, cotison and…
To investigate the underpinnings of ADHD and its persistence into adulthood: Through studying genetic factors, in combination with genomic, microbiome, cell-based, neuroimaging, neuropsychological and psychiatric assessment we aim to gain more…
the aim of this study is to compare the impact of an early-CR within 48 hrs. after PPCI to a late complete revascularization >2 weeks after PPCI on LV remodelling in patients with STEMI and multi-vessel disease.
To determine the effects of renal sympathetic denervation on insulin resistance and muscle sympathetic nerve activity (MSNA) in patients with metabolic syndrome at 3 months after renal denervation.
Major objectives:- To determine the role of small airways abnormalities in the clinical manifestations of asthma;- To evaluate which (combination of) clinical methods best assesses the abnormalities of small airways and large airways disease in…
To elucidate the molecular mechanisms underlying renal disease that lead to chronic kidney disease. To validate pathogenic variations in functional in vivo models.
The objective of this study is to investigate whether the differences in DNA methylation between individuals who were exposed in utero to the Dutch Hungerwinter (F1) and their non-exposed, same-sex siblings (F1) - as identified in epigenome-wide…