271 results
The main objective of this prospective population-based study of patients with proximal SMA in the Netherlands is to register SMA patients in the Netherlands in a socalled SMA-database to study prevalence and severity of SMA types 1-4, to perform…
Primary Objective: to study the differences in CD4+ T cell subsets (Th1/Th2/Th17/Tregulatory/Tsenescent) between GCA patients and healthy controls at diagnosis and during follow up and in remission. Secondary Objective(s): - To characterize the cell…
The aim of the project is to examine the association between clinical, environmental and genetic characteristics of the recipient of erythrocyte transfusions and the risk or resistance to immunization against erythrocyte alloantigens that he/she was…
The aim of this project is to evaluate the clinical value of biomarkers in adult patients with congenital heart disease, in particular:1) quantify biomarkers of neurohormonal activity as NTproBNP, endotheline-1 and of immunological activity as CRP,…
Within this project we aim to determine the energetic conditions that underlie the transition to hypertrophy of the HOCM heart. A prospective comparison will be made between results of PET, MRI and function of cardiac myofilaments (in vitro). Also,…
This research theme consists of two related studies with the primary aim to investigate determinants of the pathogenesis of atherosclerosis in early childhood. The first part is performed to determine the association of adipocytokines with fat…
PRIMARY OBJECTIVE1. To determine the contractile strength and the (ultra)structure of single diaphragm muscle fibers of mechanically ventilated patientsSECONDARY OBJECTIVE1. To determine whether diaphragm muscle fiber weakness is part of a…
In the current study, we want to determine and correlate the results of both perfusion capacity (with MR imaging) and sublingual glycocalyx dimensions in a) patients with proven obstructive coronary artery disease and b) patients with angina but…
To assess whether temporary discontinuation of antihypertensive therapy in mildly cognitively impaired older patients on antihypertensive treatment improves cognitive and psychological functioning.
Primary Objective: • To compare urinary concentrating capacity in ADPKD patients with healthy subjects and patient with IgA- or membranous glumerulopathy.Secondary Objectives:• To compare urinary concentrating capacity in ADPKD patients with an eGFR…
The main objective of the current study is to examine whether people with ASD have over-active inhibitory inter-connections in visual processing areas that can account for their over-sensitivity to perceptual dissimilarities.
The objective of the present study is to obtain a better understanding of tonic dystonia by quantification of the motor and sensory characteristics of the condition, and to assess the relationship between both these parameters. Specifically, this…
The major research objective is:- To examine if acute exercise results in lower hepatic lipid content and further if elevation of plasma FFAs observed during recovery from exercise results in hepatic lipid accumulation.Additional research objective…
1) identifying new predictors of ST, in particular of late and very late ST and drug eluting stent thrombosis2) to observe clinical outcome after an episode of a ST
The main aim is to validate the hypothesis by Sampson on retrograde menstruation by using modern imaging modalities. •to evaluate if the amount of blood-stained peritoneal fluid measured by TVUS and MRI during menses is greater in women with…
To compare sex differences in brain functioning using functional magnetic resonance imaging (fMRI) in healthy pre-pubertal boys and girls with a group of children diagnosed with GID. Subjects will have a second fMRI scan, as soon as they enter…
To demonstrate differences in neuronal structure and neuronal function in brain regions that control eating behaviour between obese and normal weight adolescents.
The aim of the study is to understand the nutritional status of people with complex multiple disabilitiest through measurement of body composition and nutritients.The primary objective of the study is:What percentage of people with complex multiple…
The goal of the study is to investigate the difference between heart rate variability in patients with overactive bladder and patients with stress incontinence without overactive bladder, and also the difference in heart rate variability with empty…
1. to study the effect of spironolacton and triamterene on blood pressure in anuric hemodialysis patients.2. to study the effect of treatment on body weight, serum elektrolytes, 24-hours sodium excretion, plasma aldosterone and renin concentrations…