49 results
To test the hypothesis that IVIG treatment diminish the risk of development of chronic disease, we designed a prospective clinical intervention study in children with newly diagnosed ITP.
To characterise the number, phenotype and functionality of regulatory T cells and cytokines produced in the peripheral blood of children diagnosed with asthma.
To assess whether Th17 cells play a central role in COPD, CF and pneumonia pathogenesis
What are the long-term consequences of prenatal exposure to cannabis and nicotine on the brain development of 6-year old children?
The objective of this study is to investigate the effects of replicated and theoretically interesting autism risk genes on brain anatomy in ASD. We will use psychiatric genetics and gene expression patterns to predict neuroimaging findings in ASD.
In a randomized controlled trial, the effects of DHCA and ACP during complex neonatal cardiac surgery on organ function and injury will be compared, especially focusing on cerebral damage and neurological outcome. The primary research question is…
The project aims to gain more insight in the process of bonding between parents and prenature infants, to validate a screening instrument that can be easily adopted in maternity wards of (general) hospitals to detect parents and children at risk for…
The main question in the study isHow do moderately preterm infants and their parents differ from term, as well as extreme preterm infants in (a) development and self regulation skills of the infants, (b) interaction patterns and relationship between…
1 To determine the phenotype and biological characteristics of mesenchymal stem cells derived from pediatric MDS patients as determined by flow cytometric analysis, cell culture and differentiation abilities analyzed by subtype of MDS compared to de…
To assess whether TW and PW show differences in number, phenotype or function of regulatory T-cells in peripheral blood samples. Details on study determinants will be based on the outcome of the pilotstudy (Regulatory T cells in asthma; PREDART0807…
Objective #1: Implement clinical platform. We see the need to implement a clinical platform for two purposes. First, we want to design a biomarker profile of perinatal brain damage in human newborns (see above). Thus, we have established a…
Goal of the study is to establish evidence on cognitive biases in a high risk population and on the longitudinal impact of such biases. We hypothesize that CPAD*s show biases in their information processing when compared to control children. We…
To examine the influence of genetic predisposition, genetic factors, infections and lifestyle of mother and child in relation to 1) allergic diseases and childhood astma;2) childhood overweight and obesity; 3) cardiopulmonary fitness and…
The aim of the extended follow-up of the PIAMA cohort is: To investigate changes during the ages of 8 to 11-12 years in lifestyle, nutrition, physical activity and health related attitude and behavior that are relevant to the development of asthma,…
(1) to determine the psychiatric status (ADHD and ODD/CD) for the second time in participants from ADHD and control families about 5 years after the first assessment. The participants will be between 10 and 23 years of age now; (2) to determine the…
Objective of the study: The main objective of this study is to investigate the influence of different genetic mechanisms (risk genes, CNVs and gene expression profiles) in ASD and to study the relation between the genetic heterogeneity and specific…
The objective of the present study is the evaluation of ventricular function in patients with congenital heart defects by means of newly developed echocardiographic techniques as tissue doppler and speckle traking stran rate echocardiography. Since…
The project is focused on induction of immune tolerance in allergy by prebiotics. The pathophysiology of immune modulation will be investigated and searched for potential biomarkers for immune modulation.
- To determine physical fitness in children with a congenital heart disease (ventricular septum defect, atrium septum defect, tetralogy of Fallot, transposition of large arteries and patients after a (modified) Fontan-operation) and to compare…
The overall aim of the study is to enrich the database of the Dutch IMAGE samples with (1) structural magnetic resonance imaging (sMRI) and functional MRI (fMRI) data; (2) follow-up data of clinical status (ADHD symptoms and relevant comorbidities)…