95 results
Previous studies have shown that the origin of trained innate immunity lies in the bone marrow and is determined by epigenetic and metabolic reprogramming in hematopoietic stem and progenitor cells. In this study, we investigate whether long-term…
In this study, we therefore aim to investigate how trained immunity is systemically regulated in ANCA vasculitis patients and how the degree of trained immunity affects disease activity and severity. A better understanding of these processes…
The aim is to investigate changes in nocturnal and postprandial glucose and glycogen metabolism in individuals with IFG and IGT when compared to healthy, non-diabetic, overweight participants. In addition, it will be investigated if reducing…
Primary objectives:To evaluate the pathogen host interactions between S. aureus and NS patients:o IgG and IgG4 responses against S. aureus antigens in NS patients will be compared with IgG and IgG4 responses against antigens of other bacteria (e.g.…
Primary Objective: Identify markers that distinguish between high and low rupture risk IAs.Secondary Objective(s): • Gain insight in the hemodynamic and cellular processes underlying IA rupture risk.• Determine the interrelatedness of hemodynamic…
The primary objective of our study is to evaluate sensation (static/moving pressure/touch, hot/cold temperature and pain threshold) of the face in patients with unilateral facial nerve palsy and compare the sensation of the affected side to the non-…
The main objective is to quantify neuroinflammation using [11C]SMW139 PET-scans in subjects along the AD continuum and age/sex-matched cognitively unimpaired subjects.
The main aim is to study early neurocognitive functioning and development in very young children with SCD. The secondary aims are to identify determinants (risk and protective factors) and biomarkers of early neurocognitive deficits in SCD and to…
(also see: C1. Protocol, page 9, paragraph 2)Primary: Creating a metabolic bio-database with body material of patients with inherited metabolic diseases, combined with clinical data.Secondary: Achieve better participation in national and…
Primary: - Examine longitudinal developmental trajectories of structural and functional brain metrics in relation to genetic, clinical, psychological, environmental, and cognitive information in familial high-risk offspring and control children (…
Primary Objective:Part 1: to characterize platelets of patients with Lowe syndrome using superresolution microscopy.Part 2: to characterize platelet age in patients receiving chemotherapy for AML using artificial intelligence techniques.Secondary…
To study the human adult cochlea, in specific it*s RNA and protein expression patterns and morphology.
The primary objective of this study is to investigate how the vascular regulation is altered in the maternal as well as placental vasculature of women with pregnancy disorders (preeclampsia, pregnancy-induced hypertension, FGR, preterm birth,…
To assess kidney oxygenation in obese, hyperfiltering adults with T2D before and after bariatric surgery for men and women separately determined by BOLD-MRI
Assess nutrition-related biomarkers in plasma and urine samples at ICU admission
The primary objective is to validate the LSCI against the LDPI in the assessment of the forehead DBF induced by capsaicin application and saline iontophoresis.
This study aims to add the new ASL MRI sequence to the scanning protocol of the Centrum voor Ouderengeneeskunde Amsterdam (COGA) study (METC number 2017.148), to study the BBB integrity of the subjects included in the COGA study.
To identify genetic variants for the development and progression of keratoconus using Whole Exome Sequencing and Whole Genome Sequencing approaches on keratoconus families with index patients originating from the Rotterdam Eye Hospital and Erasmus…
To assess the association between the presence of neutrophil subsets (CD16dim/CD62Lbright and CD16bright/CD62Ldim) and physical activity, physical fitness and complications in patients with esophageal or stomach cancer during curative treatment
The primary objective is to identify early signs of disease onset in asymptomatic carriers of ALS-related mutations. This will allow them to initiate treatment or partake in clinical trials in an early stage of morbidity. Secondary Objectives are…