3304 results
The objective of this pivotal study is to assess the long-term safety, tolerability, pharmacokinetics and pharmacodynamics of RP103 in pediatric and adult patients with nephropathic cystinosis. Results of this Phase 3 study will be used to support…
In the current study, we want to determine and correlate the results of both perfusion capacity (with MR imaging) and sublingual glycocalyx dimensions in a) patients with proven obstructive coronary artery disease and b) patients with angina but…
The primary objective is to explore the pharmacokinetic parameters of intravenous salbutamol in pediatric patients admitted to the intensive care unit. Secondary objectives are to explore a possible relationship between dose, plasma levels,…
To assess whether temporary discontinuation of antihypertensive therapy in mildly cognitively impaired older patients on antihypertensive treatment improves cognitive and psychological functioning.
The purpose of GRN-study is: 1. to determine the long-term effectiveness of a 12 weeks lasting physical exercise training program. 2. to determine the costeffectiveness of the 12 weeks lasting physical exercise training program. In aim of the GRN-…
Primary Objective: • To compare urinary concentrating capacity in ADPKD patients with healthy subjects and patient with IgA- or membranous glumerulopathy.Secondary Objectives:• To compare urinary concentrating capacity in ADPKD patients with an eGFR…
To determine the effect of a structured diagnostic-therapeutic strategy to detect and treat previously unrecognized or unestablished heart failure in primary care as compared to care as usual.
Marsupialization and placement of a word catheter for the management of the cyst or abscess of the bartholin gland will be studied. Medical effectiveness in terms of recurrence of the cyst or abscess after 1 year follow up will be evaluated. Patient…
Primary Objective:To assess the ability of BR55 to identify area(s) of VEGFR2 expression in human prostate by ultrasound molecular imaging on the basis of a visual score in comparison with histopathology analysis (location based on expression of…
This study aims at the questions about anterograde amnesia. How often does it occur in patients being treated with bilateral ECT for a depressive disorder, how does anterograde amnesia develop during the treatment course and how does it subside…
To improve our insight in chronic pain and to develop methodologies to treat chronic pain.
Main objective: To assess the effect of Caphosol on the number of days of mucositis > grade ISecondary objective: to assess the effect of Caphosol on duration and degree of mucositis and pain, a possible influence on the occurrence of…
Evaluating the current dosing guidelines in children taking the half-strength paediatric tablets will provide reassurance that the recommended lopinavir/ritonavir dose provides adequate drug exposure and maintains efficacy.This trial will evaluate…
The aim of the current study is to identify couplings of muscle activation patterns (muscle synergies) in reaching movements in stroke patients. Insight in the motor control of stroke patients can contribute to improve the disabled arm functioning…
Primary objectives:To establish the lowest effective dose using physiological and subjective measures of sexual arousal.To evaluate and compare the pharmacokinetics of testosterone and its metabolites following administration of three (3) doses (0.…
To investigate the HPA axis function and the glucocorticoid receptor function after high-dose glucocorticoid therapy during treatment for childhood ALL and lymphoma. With these results, a more robust approach on glucocorticoid coverage during…
The hypothesis of the FAME II trial is that FFR-guided PCI (with DES) plus optimal medical treatment is superior to optimal medical treatment alone. The overall purpose of the FAME II study is to compare the clinical outcomes, safety and cost-…
Primary: Antiviral efficacy after 48 weeks of treatment. Secundary: Antiviral efficacy after 24 weeks, safety and tolerability, resistance development, PK, incidence of HIV-associated conditions, gender-, race-, and/or HIV-1 subtype on response to…
The main objective of the current study is to examine whether people with ASD have over-active inhibitory inter-connections in visual processing areas that can account for their over-sensitivity to perceptual dissimilarities.
The objective of the present study is to obtain a better understanding of tonic dystonia by quantification of the motor and sensory characteristics of the condition, and to assess the relationship between both these parameters. Specifically, this…