1376 results
Within the proposed study design it is possible to answer more study questions within the same population and within the same timeframe without adding much burden to the study participants. measurements and analyses will be performed both during a…
Primary objective:• To assess the safety and feasibility of adding ipilimumab-nivolumab to a CRT induction protocol• To assess the efficacy of adding ipilimumab-nivolumab to CRT on the likelihood of a pCR and MPRSecondary objectives: • Local and…
The study aims to quantify differences in gastric digestion and absorption of caprine and bovine casein protein
To examine the effect of two different degludec dose adjustments on glucose profiles and the incidence of (nocturnal) hypoglycaemia after oxidative exercise in people with DM1 at elevated risk of hypoglycaemia.
The primary objective of this study is to determine the effect of three different fat blends on underlying mechanistic and immune responses in the circulation. The secondary objectives of this study are: 1) to examine the effects of the three…
Primarily, we aim to identify SNPs and transcripts that are associated with the degree of endotoxin tolerance. To increase the chances of success, the genomic and transcriptomic data obtained in vivo will be integrated with data obtained by a…
The major aim of the proposed project is to investigate the clinical relevance of early identification and adequate treatment of co-occurring sleep disorders in people suffering from mental disorders. The main questions underlying the present…
- To investigate the baseline profile and inter- and intra-subject within-day and between-day variability of the fatty-acid profiles including fatty-acid desaturation index (FA-DI) and PUFAs in the plasma of patients with Parkinson*s disease and…
The main objective of this study is to determine whether supplementation with FO combined with complex phospholipids can alter skeletal muscle mitochondrial function more effectively than FO alone. Additional exploratory objectives are;…
The primary objective in the first phase is to test the feasibility of recording hybrid IMU/EMG based movement/muscle activity parameters during different movements in the lab and at home.The primary objectives in the second exploratory phase are 1…
Do people with cluster headache exhibit an increased tendency towards risk- and reward-seeking behaviour as quantified by an array of psychometric tests and the Balloon Analogue Risk Task (BART), compared to age- and sex-matched healthy controls and…
To identify and quantify the main excretion pathways of E7727.
The primary aim of the current research is to gain insight into the background, and the precipitating factors of the suicides among adolescents aged, 10 to 20 years old, in 2017 in the Netherlands, by focusing on five domains and the last period…
The aim is to demonstrate the effectiveness of personalized and home-based speech therapy on quality of life, intelligibility and social participation for people with Parkinson*s disease who have a reduced intelligibility of speech.
To study the effect of sweetener oral rinses on the oral microbiome composition.
Primary objectiveTo determine whether aprotinin can reverse the increased postoperative blood loss, induced by dual anti-platelet therapy in elective non-complex cardiac surgery.Secondary objectiveTo determine whether aprotinin reduces transfusion…
This research is part of the evaluation of regular care.Primary objective:(1) to investigate whether 4 weekly shockwave treatments for soldiers with mid-portion Achilles tendon endopathy result in an improvement in Achilles tendon structure after 8…
With this research we look at the short-term effects of an aronia malanocarpa extract on cognitive functioning in healthy young adults compared to placebo.
To investigate in our defined HF patient population if monitoring in combination with motivation on physical activity leads to an increase in enrollment rate for cardiac rehabilitation and sustained physical activity after cardiac rehabilitation as…
In this project we hypothesize that recurrent pregnancy miscarriages is an issue stemming from both the female as the male. The overall aim is to elucidate paternal factors associated with RPL (A) and to assess the predictive value of these factors…