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Measuring Athletes* Risk of Cardiovascular Events - Exercise-Induced Cardiac Troponin Release and Coronary Atherosclerosis in Amateur Athletes

The primary aim of this explorative study is to compare exercise-induced cardiac troponin elevations between athletes with different levels of coronary atherosclerosis. The secondary aim is to compare exercise responses to other cardiac biomarkers…

Depression and Microbiota: Biological, and Psychological markers of treatment response

Primary objective: To investigate changes in biological and psychological markers for patients with an unipolar depressive disorder during treatment.. In specific, we will study the relationship between depressive symptomatology with changes in…

A PHASE 3B RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, ACTIVE CONTROLLED MULTI-CENTER STUDY ASSESSING THE EFFICACY AND SAFETY OF ABROCITINIB COMPARED WITH DUPILUMAB IN ADULT PARTICIPANTS ON BACKGROUND TOPICAL THERAPY WITH MODERATE TO SEVERE ATOPIC DERMATITIS

Primary:To compare the efficacy of abrocitinib 200 mg once daily (QD) versus dupilumab (as per label guidelines) in adult participants on background topical therapy with moderate to severe atopic dermatitis (AD).Key SecondaryTo compare the efficacy…

A Single-Dose, Open-Label, Randomized, Replicate Crossover Pivotal Bioequivalence Study in Healthy Subjects to Assess the Bioequivalence of Darunavir 675 mg, Emtricitabine 200 mg, and Tenofovir Alafenamide 10 mg in the Presence of Cobicistat 150 mg when Administered as a Fixed Dose Combination (Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide) Compared to the Coadministration of the Separate Agents (Darunavir, Cobicistat, and Emtricitabine/Tenofovir Alafenamide), Under Fed Conditions

- To evaluate the single-dose PK and pivotal bioequivalence of 3 compounds darunavir (DRV) 675 mg, FTC 200 mg, and tenofovir alafenamide (TAF) 10 mg in the presence of cobicistat (COBI)150 mg when administered as an fixed-dose combination (FDC) (D/C…

Fear generalization: a direct replication of Lissek et al. (2010)

The main goal is to test whether individuals with a panic disorder diagnosis differ in the level of fear generalization compared to matched controls. This would be a direct replication of the seminal study by Lissek et al. (2010).

A randomized, double-blind, placebo- and active comparator-controlled, crossover trial to examine the effect of multiple doses of CVL-865 on panic symptoms induced by carbon dioxide inhalation in healthy subjects

Primary: To investigate if CVL-865 decreases subjective anxiety symptoms elicited by a 35% CO2 inhalation challenge.Secondary: To investigate if CVL-865 decreases subjective fear symptoms elicited by a 35% CO2 inhalation challenge. To investigate if…

A Single-Center, Prospective Study in Healthy Volunteers for Validation of the O3 Regional Somatic Tissue Oxygenation Monitor

The objective of this study is to assess the performance of the Masimo O3 regional oximeter on somatic tissue oxygenation, under controlled hypoxia. Somatic rSO2 values will be compared with combined arterial and venous blood gas measurements from…

Postbariatric EArly discharge Controlled by Healthdot

To evaluate whether performing bariatric surgery as outpatient surgery is not inferior to the current treatment based on a combined outcome measure.

The enrichment of the fat graft in facial fat grafting for increased volume retention

The comparison of standard fat grafting with enriched fat grafting.

Sweet tooth: Nature or Nurture? Role of long-term dietary sweetness exposure on sweetness preferences

To assess the effect of a 6-month regular, low and high dietary sweetness exposure on sweetness preferences, food intake, glucose homeostasis and body weight in healthy adults.

A pilot study on oral esketamine for depression and demoralization in patients with advanced cancer receiving palliative care

Evaluation of the feasibility of a trial on the efficacy of oral esketamine for the treatment of depression and/or demoralization in patients with advanced cancer who receive palliative care.

Phenotypical and Pathophysiological Characterization of Patients with Alcohol-related Liver Disease.

The primary objective of the study is to identify, develop and validate non-invasive biomarkers for the assessment of alcohol use in patients with ALD. This by determining ethylglucuronide in hair, nail and urine in this population. By validating…

The effect of a single gift antibiotics before ERCP to prevent post-ERCP pancreatitis.
A study protocol for a single centre, double blinded randomized controlled study.

This study aims to further reduce the incidence of a post-ERCP pancreatitis by administrating a single gift antibiotics after the procedure.

Quantifying various effects of closed-loop Spinal Cord Stimulation (SCS) on pathophysiological mechanisms in Complex Regional Pain Syndrome (CRPS); an explorative study

To evaluate and quantify the various clinical effects of closed-loop SCS versus open-loop SCS on the underlying pathophysiological effects in CRPS.

Prognostics in the Treatment Evaluation of the National System for Veterans' Care

The primary objective of this project is to investigate whether using prognostic factors from the PD, NP and PP domain will lead to a better prediction of treatment outcome in veterans with PTSD. Our secondary objective is to investigate whether the…

Continuous low dose subcutaneous lidocaine for treatment of pneumonia in COVID*19 patients.   A randomised controlled (RCT) open*label phase III study.

The disappearance of the main symptoms of the COVID*19*induced pneumonia within 5 days after the initiation&…

What are reference values of the thickness and the thickening fraction of the diaphragm in children aged 0-8 years?

Primary objective: To determine diaphragm thickness and thickening fraction in healthy children below or equal to 8 years of age.Secondary objective: To determine the interrater reliability of operators performing the ultra-sound

Liver glycogen dynamics and substrate oxidation in lean healthy volunteers (Follow-up study on study entitled *The effect of modulating hepatic glycogen content on hepatic fat oxidation*)

The primary objective of this study is to examine to what extent hepatic glycogen is decreased after a prolonged overnight fast in healthy volunteers with a normal weight and low liver fat percentage.

Novel Empowering Solutions and Technologies for Older people to Retain Everyday life activities

The objective is to validate the NESTORE Platform in relation to three main evaluation criteria: For (1) Feasibility, we will evaluate the validity and the appropriateness of the procedures for the proposed intervention. For (2) Usability and (3)…

Feasibility of wireless cardio-respiratory monitoring with a belt in preterm infants

The objective of this explorative study is to determine the feasibility of measuring dEMG with a belt in preterm and term born infants during routine caregiving. Feasibility is confirmed when heart rate and respiratory rate reach a predefined level…