56 results on atopic dermatitis
Primary objectives:• To explore whether daily oral treatment with 30 mg prednisolone modulates biomarkers for adverse metabolic effects in a similar manner in patients with chronic atopic dermatitis as compared to healthy volunteers.• To determine…
Primary study objectiveTo investigate the prevalence of asthma in children up to 7 years of age with atopic dermatitis in infancy who received either Nutrilon Pepti with synbiotics or Nutrilon Pepti without synbiotics during 12 weeks in their first…
To determine the frequency and suppressive potential of skin resident regulatory T cells isolated from atopic dermatitis and psoriasis patients compared to healthy control subjects (the latter data will be obtained by co-workers at the Brigham and…
To assess long-term safety, tolerability and efficacy of upadacitinib in adult subjects with moderate to severe atopic dermatitis who successfully completed treatment in the M16-046 study. Efficacy will be evaluated through Week 52, and safety and…
Primary objective:Assess the efficacy of rilzabrutinib in participants with atopic dermatitis (AD)Secondary objectives: * Assess the efficacy of rilzabrutinib at different time points* Assess the safety of rilzabrutinib
Investigate the role of CD8+ T cells in AD by:a. Isolation of T cells from the skin and determination of the percentage and phenotype of CD8+ T cells in both acute and chronic AD, using the APT as an in vivo induction model. Comparison with…
Primary objective: To evaluate the efficacy of once daily doses of QAW039, as measured by EASI after 12 weeks of treatment, relative to placebo, in adult patients with moderate to severe AD. To evaluate safety and tolerability.Secondary objectives:…
To compare the MC with the UK working party diagnostic criteria (UKC) and clinical diagnosis and to refine the MC into a more convenient and reliable set of criteria.
To perform a comprehensive analysis of the cellular infiltrate in lesional AD skin, using state of the art immunohistochemical techniques.
To compare the efficacy and safety of methotrexate versus azathioprine treatment in adult patients with chronic severe AD.
We wish to study the absolute numbers, ratio and phenotype of CD27+IgE+ and CD27-IgE+ memory-B-cells in blood of atopic children who suffer from proven IgE-mediated asthma/hay fever, atopic dermatitis or food allergy and compare these with healthy…
The primary goal is to evaluate the presence and type of skin disorders in patients with a PID. Secondary objectives are to determine the presence of S. aureus on the lesional skin and/or nose in patients with a PID and to evaluate the presence of…
To investigate the therapeutic effect of a selected probiotic mixture on the severity of AD in infants aged 0-15 months. The probiotic mixture has been studied in vitro and has proven IL-10 stimulating effects. Therefore it is thought to decrease AD…
Determine the frequency, phenotype and function of disorder-related immune cells, or levels of immune molecules in skin and peripheral blood of patients with inflammatory skin diseases, during the active phase of disease prior to and/or at any time…
Primary objective is to determine the actual occurrence of and risk factors for OCD on the hands of Dutch construction workers.With these new insights into the risk factors for OCD, we aim to develop 1) a new diagnostic tool to be used by…
To assess the safety and efficacy of DBV712 in initiating desensitisation of peanut in children aged 1 to 3 years with peanut allergy, after 12 months of treatment with Epicutaneous Immunotherapy EPIT).
To define differences in the molecular composition of human milk extracellular vesicles between allergic and non-allergic mothers. Additionally, other differences in human milk composition will be analyzed (cellularity, nutrient content,…
Primary Objective: 1) We want to investigate whether carriers of FLG-null mutations show higher responses to exposure to the skin irritant SLS than non-carriers.2) Furthermore, we want to investigate whether carriers of mutations in the genes coding…
The objectives of this follow-up study of the EPITOPE study are:• To assess the clinical benefit of Viaskin Peanut after up to 3 years of epicutaneous immunotherapy (EPIT) to induce/maintain desensitization to peanut in peanut-allergic children;• To…
PrimaryTo evaluate the long-term safety and tolerability of baricitinib in patients with SLE.