21 results on atopic dermatitis
The aim of the project is to gain more insight of the OX40/OX40L expression patterns in atopic dermatitis. This information can be used to adapt the design of subsequent in vitro/ in vivo research, clinical research, but also the development of the…
Primary Objective: To investigate longitudinal variation of blood-based biomarkers, their integration with disease severity, comorbidities, their association with standard care and characterization of adequate and inadequate responders to standard…
The aim of the project is to further develop and evaluate skin disease models by investigating the synthesis and cytokine release in atopic dermatitis lesions. This information can establish the right formulation of new medicines for further in…
The primary goal is to evaluate the presence and type of skin disorders in patients with a PID. Secondary objectives are to determine the presence of S. aureus on the lesional skin and/or nose in patients with a PID and to evaluate the presence of…
To develop and validate transplant models of vitiligo and atopic dermatitis for drug testing.
To define differences in the molecular composition of human milk extracellular vesicles between allergic and non-allergic mothers. Additionally, other differences in human milk composition will be analyzed (cellularity, nutrient content,…
The purpose of the study is to investigate how quickly and to what extent PF 04965842 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). A small part of the PF 04965842 to be…
Primary Objectives- To characterize the dermal immune response of healthy volunteers following a UV-B skin challenge- To characterize the dermal immune response of CLE patients following a UV-B skin challenge on non-lesional skin- To evaluate the…
The specific aim of the project is to determine the efficacy of Spherical Nucleic Acids (SNAs) on psoriasis skin biopsy gene expression in vitro.
The specific aim of the project is to determine the efficacy of Spherical Nucleic Acids (SNAs), delivered in a gel, on psoriasis skin biopsy gene expression in vitro.
To quantify and assess intra- and inter-subject variability in mast cell density among healthy male and female volunteers. Serum tryptase values will also be quantified.
Is CMPX-2030 effective in the transplant model of psoriasis
To compare the new IMF with the control IMF.
To characterize the response to intradermal LPS by:- Clinical measures- Biophysical measures- Imaging- Molecular and cellular responses- Routine safety measures
Primary Objectives- To determine the effect of the heat plate on suction blisters in a LPS challenge modelSecondary Objectives- To evaluate the safety and tolerability of the heat plate added to the LPS challenge model;- To evaluate the correlation…
Primary objectives• To evaluate complement activation after topical imiquimod challenge• To evaluate complement activation after local UV-B challenge
To evaluate local complement activation/depositions after intradermal LPS challenge
• To investigate the microbiome composition of the nares, non-lesional skin and patches, plaques and tumours in lesional skin of CTCL patients, including all stages of the disease• Correlate microbiome (including S. aureus presence) and disease…
The goal of this study is to validate and interpret a new HRQOL instrument and to analyse commonly used outcome measurements (PGA, PtGA) in dermatology.
Objective: determine whether a Likert-type scale scoring system, specified for skin irritation reactions (erythema, itching, burning sensation of skin and general irritation of skin) can function as a tool to score the radiation-induced dermatitis…