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Prognostic value of a Non-invasive surrogate for right ventricular pressure-volume loops

Objective: The overall aim of this project is to asses the prognostic value of the characteristics of an echocardiographic surrogate pressure-volume loop on mortality and morbidity due to PAH.

A randomized, placebo and active comparator (oxycodone)- controlled study on the effect of tapentadol on respiration and analgesia in healthy volunteers

At equi-analgesia respiratory depression from oxycodone is manifold greater compared to Tapentadol

AAA study

The administered protein mix is related to a faster postprandial amino acid bioavailability compared to a single protein as measured by the t½ of the iAUC.

SmartGlasses for freezing of gait in Parkinson’s disease

We have developed a cueing application (app) for the Google Glass platform that can guide gait in PD-patients. Our initial observations showed that external cueing with the Google Glass application decreased the number and duration of FOG episodes…

Pharmacokinetics of Lorazepam Oral Liquid in Paediatric ICU Patients

BOSS: "Bioequivalence of oral protein supplements after bolus intake in healthy elderly"

To investigate whether amino acid area under the curve (AUC) and Cmax of product B is equivalent to amino acid AUC and Cmax of product A

Haalbaarheidsstudie: Onderzoek naar het effect van twee gezonde voedingspatronen op lichamelijke en psychische klachten.

Different studies have shown that a hunter-gatherer type diet is effective in improving glucose regulation and lipid profile. I want to investigate if the hypothese that this type of diet also reduces the number of physical and psychological…

Parathyroidectomy versus cinacalcet for the correction of secondary hyperparathyroidism in hemodialysis patients

Total parathyroidectomy (PTX) in patients with secondary hyperparathyroidism (HPT2) is a more effective treatment than the use of Calcimimetica.

EFFECT-FD: Effect of adding bezaFibrate to standard lipid lowering therapy on non-Fasting CholesTerol in patients with Familial
Dysbetalipoproteinemia

Bezafibrate will significantly reduce post-prandial non-HDL cholesterol in patients with Familial Dysbetalipoproteinemia compared to placebo.

Thermal challenges in modern day humans

This study aims to chart which thermal challenges modern day humans are exposed to and compare this to their thermoneutral zone. Therefore we hypothesize that modern day humans (both males and females) are predominantly within their thermoneutral…

Rotation for Optimal Targeting of Albuminuria and Treatment Evaluation

FitSupport; leefstijlverbetering bij supporters

The main objective of the FitSupport study is to include 3000 supporters of the soccer clubs into the intervention through two different inclusion strategies; one digital and one personal recruitment strategy. These participants will be divided in…

Rotation for Optimal Targeting of Albuminuria and Treatment Evaluation

Bioequivalentie van eiwit supplementen na bolus inname in gezonde ouderen

Het doel van dit onderzoek is om te bepalen of 2 soorten eiwitten bio-equivalent zijn aan elkaar m.b.t. het opnameprofiel bij gezonde vrijwilligers na eenmalige orale bolus inname.