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Self-perceived symptoms and care needs of patients with severe to very severe chronic obstructive pulmonary disease, congestive
heart failure or chronic renal failure and its consequences for their closest relatives.

Patients with moderate to severe COPD, CHF or CRF have been shown to suffer from exercise intolerance, muscle weakness and abnormal changes in body composition, irrespective of the degree of primary organ failure. Therefore, it seems reasonable to…

Mesenchymal Stem Cells for the treatment of Crohn's Disease

It is safe and feasible to administer autologous bone marrow derived MSCs for treatment of Crohn's Disease (CD).

Reducing the prescription of antibiotics in newborn infants, suspected for an early onset sepsis.

Is it possible with the course of cytokines in the first two days of life to start antibiotics selectively in infants suspected for an EOS (early onset sepsis) and to stop prescribing antibiotics in infants who already receive antibiotics

Development of a quick and easy malnutrition screening tool for hospitalized children: the short nutritional assessment questionnaire (SNAQkids)

The recognition of malnourished children will improve by using the short nutritional assessment questionnaire.

Stress and psychosis.

- The level of psychotic reactivity differs between psychotic trait, state, and illness groups - Psychotic reactivity is mediated by biological reactivity in terms of dopamine and cortisol reactivity - The level of psychotic reactivity is…

Optical imaging for improved detection and surgery of solid tumors

To test if an intraoperative NIRF camera system can detect a NIRF optical contrast agent for SLN in patients with palpable breast cancer.

Nocturnal Free Fatty Acids. Measurements in obese and lean subjects
and the effect of â-blockage on pulsatile release.

Nocturnal FFA levels are higher in obese insulin resistant subjects and are less sensitive to the FFA lowering effects of a â-receptor blocker.

Effect, Safety and Pharmacokinetics Study of PRO051 to Treat DMD

Estetrol Therapy in Sjögren’s Syndrome: An Open Proof of Concept

N/A

Open label study to establish the efficacy of intravenous loading doses of Ibandronate 6 mg in patients with lung cancer and skeletal metastases experiencing moderate to severe bone pain: NVALT 9.

In lungcancer bone metastases appear frequently en they are an important cause of pain. The expectation is that Bondronat® gives a fast pain reduction. In this phase II study will be examined whether this fast pain reduction indeed occurs and if…

An electronic nose in the screening for COPD in an at risk population of (ex-)smokers.

We postulate that exhaled breath sampling by an electronic nose can adequately identify newly presented patients with COPD in an at risk population ((ex-)smokers), regardless of symptoms.

The evaluation of renal damage caused by iodinated contrast media used to enhance images in computer tomography scanning by assessing multiple serum and urinary parameters.

1. Pre- and post-hydration using a sodium bicarbonate infusion scheme is an effective method to prevent CIN from occurring. 2. The current protocol is efficient in identifying high risk patients. 3. Microalbuminuria and microglobulinuria can…

Safety and Efficacy clinical trial of the PTMA System to reduce mitral valve regurgitation in heart failure.

Reduction of the severity of functional mitral regurgitation using a percutaneously delivered implanted device.

A diagnostic studie:
Mannitol challenge test in patients with mild to moderate COPD

To investigate the diagnostic value of the mannitol challenge test compared to the eosinophilic inflammation in the airways.

The diagnostic accuracy of exhaled breath fingerprinting by eNose in diagnosing asthma and atopy.

We postulate that exhaled breath sampling by an electronic nose can distinguish and adequately identify smell-prints from: 1. Atopic patients without airway obstruction 2. Non-atopic patients without airway obstruction 3. Atopic patients with…

The value of diffusion-weighted MR imaging and biomarkers in cerebrospinal fluid in acute spinal cord injury as predictors of outcome.

Prospective study determing whether MRI-Diffusion Weighted Imaging (DWI) and biomarkers in CSF have prognostic capabilities in patients with Spinal Cord Injury (SCI).

Connectivity and networks in epilepsy patients with cranial tumors

- Epilepsy patients with brain tumours show altered functional connectivity and networks in the brain compared to healthy controls - Connectivity and networks change over time as a function of treatment

Sentinel Node And Recurrent Breast cancer

Due to surgery and radiotherapy lymph drainage pathways in recurrent breast cancer could be altered. These aberrant drainage pathways could be detected with lymphatic mapping and sentinel node biopsy leading to a more thorough staging and possible…

Efficacy and safety of home treatment versus in hospital treatment with LMWH in patients with non-massive pulmonary embolism

Outpatient LMHW treatment in patients with objectively proven non-massive pulmonary embolism is efficacious and safe.

Evaluation of the clinical impact of ventricular dyssynchrony in patients with corrected tetralogy of fallot

Improvement of the RV function by pulmonary valve replacement will result in improvement of RV dyssynchrony in corrected tetralogy of Fallot patients