63 resultaten
To develop a dosing nomogram of irinotecan in patients homozygous polymorphic for UGT1A1*28 and/or UGT1A1*93 in order to reduce the incidence of severe irinotecan-associated toxicity, defined as febrile neutropenia in the first 2 cycles (amendment…
The gastric balloons are expected to remain in the stomach for approximately four weeks, after which they burst and are fecally excreted. It is further hypothesised that intragastric balloons can provide a surrogate stomach fill, inducing an…
The RAINBOW study: Rheumatoid Arthritis ImplemeNtation of Biological dose Optimization in real World
We hypothesize that a multifaceted implementation strategy can stimulate the use of tight control and bDMARD dose optimization in clinical practice, measured by decreased bDMARD use and non-inferiority on disease activity at 18 months.
Nebulizing amoxicillin clavulanic acid is more effective for reaching amoxicillin levels in sputum > MIC90 than amoxicillin clavulanic acid given by oral or intravenous administration.
1. It is hypothesized that participation in the Active plus program contributes to an increase in physical activity behaviour among older adults; 2. Additionally receiving physical and social environmental information results in an extra increase…
Chronic allograft nephropathy is the main cause of long-term renal transplant failure. The pathogenesis involves amongst others calcineurin inhibitors. We performed a multicenter randomized trial to study the effects of withdrawal of ciclosporin (…
we hypothesize that an electronic nose can discriminate the VOC pattern in exhaled breath between patients with colorectal cancer and healthy controls.
rt-PA administration by retinal branch vein way in CRVO patients improves final BCVA.
we hypothesize that an electronic nose can discriminate the VOC pattern in exhaled breath between patients with Head and Neck Cancer from healthy controls.
Does lipid accumulation in skeletal muscle and the heart effect mitochondrial function in relation to insulin resistance?
Simvastatin (an HMG-CoA reductase inhibitor) induces apoptosis in vitro and sensitizes the myeloma cell to chemotherapy. This is the first clinical trial to test if in vivo there is the same sensitization in relapse or refractory multiple myeloma.
The relative risk of developing macular edema in diabetics after cataract surgery is enhanced.
The aim of this study is to compare the efficacy of EBRT versus SEMS insertion for palliation of dysphagia symptoms in patients with esophageal cancer
It is hypothesized that the FitMáx© questionnaire is a valid clinical assessment tool for CRF compared to the gold standard, a cardiopulmonary exercise test. Moreover we believe the FitMáx© to be fairly accurate in the preoperative risk assessment…
It was hypothesized that comparing the course of uveitis of individual eyes with respect to inflammatory activity and visual acuity (VA), and the impact of particular therapies, to already available data about course and outcome from other patients…
Primary objective: To assess the efficacy of thromboprophylaxis with high prophylactic dose LMWH as compared with standard care without systemic thromboprophylaxis in children treated for primary ALL. Secondary objectives: 1. To assess the safety…
Antipsychotics (haloperidol) can cause acute changes in cardiovascular functions, metobolic parameters and platelet aggregation in elderly patients.
Because the aim of this observational study is to obtain insight in the nutrient and fluid intake, and nutrient and biomarker concentrations in the blood in patients with ischemic stroke, the focus will be on descriptive statistics and there will be…
We hypothesize that the circulatory and cardiac effects of TEA will be most pronounced during circumstances of increased sympathicotonus, which will be induced by an exercise test on a bicycle.