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1. Gatekeeper training is effective in enhancing relevant skills 2. Gatekeeper training will diminish rates of (attempted) suicides at regional level 3. The intervention is cost-effective relative to routine medical care
Surgical procedures are accompanied by high levels of distress and pain in the adult as well as the pediatric population. Music interventions have shown to reduce this anxiety and pain in adult populations. In this study, we will investigate the…
In this randomized, single blinded controlled trial, we evaluate the role of ketamine as an analgesic component of procedural sedation. We compare the effects of propofol-ketamine versus propofol-alfentanil and propofol-remifentanil for achieving a…
At equi-analgesia respiratory depression from oxycodone is manifold greater compared to Tapentadol
Multidisciplinary, goal-attained and individualized rehabilitation after knee arthroplasty will result in more satisfaction regarding activities (level of activities and overall satisfaction) in younger knee arthroplasty patients (<65 years).
The hypotheses of this study are that parents at increased risk of parenting problems who receive the intervention Solid Parenting (“Stevig Ouderschap”) during the first 18 months after childbirth, will enhance their social support network and…
1. does pseudophakia influence intra ocular pressure (IOP) lowering effect of SLT? 2. the effect of SLT relies on an inflammatory reaction. Anti-inflammatory therapy is often used immediately following SLT, does this influence the IOP lowering…
Motivational interviewing has a positive effect on footwear adherence in diabetic patients at high-risk of foot ulceration.
The administered protein mix is related to a faster postprandial amino acid bioavailability compared to a single protein as measured by the t½ of the iAUC.
The primary aim is to determine whether a regular (hot-to-) cold shower can have a beneficial effect on immune function by reducing sickness absence. Secondary aims are to determine effects on quality of health and work productivity.
Prior studies have shown reagent dependent differences in sensitivity to circulating clotting factor VII (FVII). This reagent dependent sensitivity to FVII can explain the INR differences between laboratory methods and point-of care devices found in…
We hypothesize that receiving behavioural triggers, sent as text-messages via a smartphone app, results in increased diabetes self-management of type 2 diabetes patients on insulin therapy, and subsequently to improved glycaemic control, less weight…
A major depressive disorder is a common mental disorder in the general population. It has major influence on functioning in daily life. Depression can lead to cognitive, social and physical problems and has a negative impact on the quality of life.…
Consuming most calories at breakfast compared to at dinner leads to more suppression of appetite and craving and enhances insulin sensitivity.
We hypothesise endo/epicardial substrate homogenization in a first approach to be superior to endocardial substrate homogenization alone, in terms of recurrence on follow-up.
Snare resection is non-inferior to hysteroscopic morcellation and snare resection is cost-effective.
1. The immediate intervention group will show significantly larger reductions in PCBD, PTSD and MDD at the one week post treatment assessment compared to the one week pretreatment assessment of the delayed intervention group. 2. The treatment effect…