322 resultaten
Brown adipose tissue (BAT) is thought to be involved in human glucose and lipid metabolism, however the mechanisms by which this adipose tissue is activated remain to be elucidated. Recent data in db/db mice have suggested that oral butyrate has…
Because of the high colorectal cancer (CRC) risk, Hodgkin lymphoma (HL) survivors should be offered colonoscopy screening, which has the potential to reduce CRC incidence and mortality. However, the diagnostic yield, cost-effectiveness and burden of…
We expect that tDCS will enhance speed of language recovery, resulting in improved communication, quality of life and participation - associated with decreased rehabilitation consumption and cost reduction.
1) FeNO, blood eosinophils and total IgE will have a moderate diagnostic accuracy to detect sputum eosinophilia in adult-onset asthma patients. 2) There will be differences in accuracy between sub-groups of patients.
Electrophysiological connectivity between ATN and cortical zones involved in the epilepsy of the patient in question relates to treatment response
Analysis of the lymphatic drainage pattern using 99mTc-Senti-Scint identifies the same SNs, but fewer higher-echelon nodes, as when ICG-99mTc-nanocolloid is used.
We hypothesize that HFOs recorded non-invasively with MEG and scalp EEG are biomarkers of disease activity like iEEG HFOs
To establish the yield of pancreatic cyst surveillance, based on the recently published European consensus statement, and to identify possible alternative, more (cost) effective, surveillance strategies.
Primary objective: To determine the safety of once daily inhalation of the recommended daily dose of tobramycin with the Akita® and the PARI-LC® Plus nebulizer in patients with CF. Systemic absorption can be used as surrogate parameter for safety.…
The individual counselling intervention will significantly
Increasing medication adherence in rheumatoid arthritis (RA) might reduce disease activity and the need to prescribe more expensive (biological) anti-rheumatic drugs. The usage of drug monitoring devices (like Medication Event Monitoring System (…
Primary objective: to investigate which strategy of offering vegetables in different gradients of tatste is most effective to increase children's vegetable intake. We expect that the vegetable offered in the diluted group and the vegetable…
Monotherapy with aspirin or oral anticoagulation after TAVI is safer than the addition of clopidogrel for 3 months, without being less clinically beneficial.
This study focuses on PTSD due to repeated and prolonged interpersonal abuse in childhood (eg sexual and / or physical abuse) within the immediate environment. By using a Randomized controlled design, we examine whether Imaginary Exposure is more…
In this protocol we will study the value of selinexor as the third agent based on its unique mechanism of action and reported synergy with bortezomib in patients with progressive or refractory MM.
The purpose of this study is to gain experience in diagnosing Postoperative Cognitive Dysfunction (POCD) and its risk factors in surgical patients from the age of 65 years undergoing a surgical procedure for a solid malignant tumor.
Taken together, a profound understanding of the [18F]FDHT pharmacokinetics could lead to an optimization of the [18F]FDHT PET diagnostic potential; integration of DCE MRI and PET parameters would allow for a clinically feasible method with PET-MRI.…
The aim of the pilot trial is to: 1. evaluate the potential effectiveness and effect size of the online self-management program for Rheumatoid Arthritis patients 2. to identify outcome measures most likely to capture potential patient benefit; 3…
The effects of the inflammatory response to a surgical procedure on postoperative cognitive decline in elderly cancer patients will be investigated. Preoperative inflammation level, muscle strength, nutritional status and general functioning will be…
The hypothesis is that modarate and late preterm infants at age 12 reported more symptoms consistent with asthma and use more asthma medications, as well as a poorer lung function, exercise capacity and Lung Clearance Index than healthy peers.