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Observational cohort of patients treated with stereotactic radiotherapy for Oligo LYMPh nOde and other soft tissue metastasiS; the OLYMPOS cohort

The main clinical challenge remains to identify patients who may benefit from aggressive local treatment (stereotactic radiotherapy, SBRT) of soft tissue oligometastases: for which patients can systemic treatment be postponed? Patients who are…

Minimization of maintenance immunosuppression early after renal transplantation.

Chronic allograft nephropathy is the main cause of long-term renal transplant failure. The pathogenesis involves amongst others calcineurin inhibitors. We performed a multicenter randomized trial to study the effects of withdrawal of ciclosporin (…

Lipid-induced insulin resistance.

Administration of a lipid emulsion consisting of long-chain triglycerides (LCT-trial) in non-trained individuals, will induce insulin resistance due to increased DAG accumulation and subsequent activation of the PKC pathway in skeletal muscle.…

Effect of a new synbiotic mixture of short chain galacto-oligosaccharides, long chain fructo-oligosaccharides and Bifidobacterium strain on the gut microbiota of caesarean delivered infants.

The study will investigate the effect of a synbiotic test product compared to a control product on the composition and metabolic activity of the gut microbiota of C-section delivered infants.

Hypoallergenicity of an extensively hydrolyzed whey protein infant formula in children with cow's milk allergy.

The formula will be tolerated by at least 90% of the children with cow's milk allergy with a confidence interval of 95%.

De invloed van rookstatus op de behandeling van longkanker met immunotherapie

Mortality will be lower in patients who do not smoke during treatment of non-small cell lung carcinoma with PD-L1-inhibitors compared to patients who smoke during their treatment with PD-L1-inhibitors.

Contact-based Intervention for Infants during Transition to Centre-based Care

1. Compared to the control group, 4 weeks and 8 weeks after the start of centre-based care infants in the intervention group will show: - Lower morning and afternoon levels of salivary cortisol - Less disruption of the gut microbiota and an improved…

Lipid-induced mitochondrial dysfunction in type 2 diabetes.

Does lipid accumulation in skeletal muscle and the heart effect mitochondrial function in relation to insulin resistance?

Catheter ablation versus Amiodarone to pRevent Future shock Episodes in patients with a defibrillator and a history of a myocardial infarction.

It is assumed that recurrence of appropriate ICD shocks is 30% in the Amiodarone group and 16% in the Ablation group.

Fluoxetine and the developing brain.

Administration of fluoxetine during late brain development (adolescence), but not in adulthood, will result in abnormal outgrowth of the 5-HT system. This long-lasting disturbance of the 5-HT system may be visualized using MRI techniques and can…

Macular Edema following cataract surgery
in Diabetic type 2 patients.

The relative risk of developing macular edema in diabetics after cataract surgery is enhanced.

TightRope AcromioClavicular Study; TRACS.

Acute Rockwood type 3 AC-luxations will have a better function after operative treatment with the artroscopic TightRope technique than patients treated conservative.

Convalescent antilichaam gemedieerde behandeling van COVID-19 infecties bij patiënten met B-cel disfunctie, een gerandomiseerde studie (COVID-Compromise Studie).

Er zijn meldingen gemaakt van een ernstiger verloop van COVID-19-infecties bij patiënten met een verminderd immuunsysteem, zoals patiënten met aangeboren immuunafwijkingen, (hematologische) maligniteiten of patiënten die medicatie gebruiken die het…

Klinische evaluatie van het CARMAT-kunsthart voor patiënten met eindstadium hartfalen

Het doel van deze klinische studie is het aantonen van de veiligheid en prestatie van het CARMAT-kunsthart in patiënten metvergevorderd hartfalen.