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Army Low Back Training Study.

Efficacy of minimal intervention strategy (isolated training of the lumbar extensors) with the use of a control group receiving usual care.

Diagnostic blockade of sacroiliac joint in patients with pseudoradicular low back pain.

1. In patients with non-specific low back pain, 10 ml lidocaine 2% reduce the pain more then 2 cm at the BOX-score compare to the placebo group; 2. In patients with non-specific low back pain, 9 ml lidocaine 2% with 1 ml corticosteroid (40 mg…

Chemoradiation for irresectable (T4) esophageal cancer, a phase II multicenter study.

Chemoradiation therapy for irresectable T4 esophageal tumor improves response rate and survival compared to radiotherapy alone.

A comparison of widely used clinical contrast sensitivity tests: the relation between defocus specific contrast sensitivity and higher order aberrations.

Higher order aberrations, like spherical aberration, decreases visual performance.

Sleep position related to hospital length of stay in admitted COVID-19 patients

Predominantly sleeping in the non-supine position could improve oxygenation and thereby shorten the disease course in admitted COVID-19 patients.

Amino acids in type 2 diabetes

We hypothesize that patients with type 2 diabetes and first-degree realtives of patients with type 2 diabetes are characterized with a diminished branched-chain amino acid oxidative capacity

Intestinal imidazole propioNaTE productioN after histiDinE supplementation in healthy and type 2 Diabetes mellitus subjects:
role of the gut microbiota

Histidine supplementation will lead to higher plasma ImP levels in T2D patients, but not in healthy controls and this effect is mediated by the gut microbiota.

Introduction of a breast cancer care programme in ultra short stay (ambulatory/24 stay setting) in 4 early adopter centres: implementation and evaluation.

There is no hypothesis in this implementation study, that is designed to record facilitating and inhibiting factors when an accepted and well functioning care programme is introduced in four early adopter hospitals.

Remission induction in early rheumatoid arthritis.

Early and aggressive treatment of rheumatoid arthritis according to a strict treatment protocol results in a 70% remission of the disease within 2 years.

The effect of oxytocin on brain processes in PTSD.

We expect that OT administration in PTSD patients and controls will dampen amygdala activity and increase reward sensitivity. We hypothesize to see a group by treatment interaction effect, such that the magnitude of the neural effects of OT…

Simply Capecitabine in rectal cancer after irradiation plus TME.

The overall survival in the arm treated without chemotherapy (TNM-stage II or III tumours) is expected to be approximately 60%. Assuming an improvement in overall survival from 60% to 70% in the arm treated with chemotherapy (TNM-stage II or III…

CROSS II.

Surgery is the standard therapy for esophageal cancer. However, 30% of the resections are irradical. It is thought that preceding chemoradiotherapy will improve the surgery results.

Compare fine motor skills of children: Visual impaired and normal vision.

Fine motor skills of visually impared children will be slower and less accurate compared to normally sighted peers.

A clinical trial to test if Ruconest causes immunological reactions in healthy volunteers who are allergic to cow's milk and/or rabbit.

A SPT has been proposed to screen subjects with increased risk of hypersensitivity reaction to Ruconest. Subjects with RA and subjects with clinical CMA have an increased risk of hypersensitivity: although cow's milk proteins differ from rabbit…

Comparison of melatonin, temazepam and placebo for the treatment of sleep problems in hospitalized older patients.

Acutely hospitalized older patients frequently suffer from inadequate sleep. Insufficient sleep can lead to patient distress and delayed recovery from acute illness or a surgical procedure. Currently, no evidence-based treatments exist for sleeping…

Complications of diabetes mellitus in primary care: a survey.

General practitioners and nurse practitioners are not aware of the association between diabetes mellitus and limited joint mobility (LJM), and therefore do not screen diabetic patients for musculoskeletal complaints of the upper extremity.

Open randomized study of previously untreated metastatic prostate cancer patients comparing intermittent to continuous treatment with cyproterone acetate. Evaluation of step-up therapy adding an LHRH agonist upon progression is included.

Intermittent androgen deprivation using CPA oral monotherapy improves the overall quality of life while achieving similar control of tumour growth to that attained by continuous CPA treatment.

Effect of Genestein as food supplement in patients with Sanfilippo syndrome.

Genestein inhibits the synthesis of heparan sulphate and can possibly slow down disease progression in Sanfilippo Syndrome patients.

Thrombin Generation after Abrupt Cessation versus Weaning over 8 hours of Continuous Infusion of Unfractionated Heparin in ICU-patients after Discontinuation of Continuous Venovenous Hemofiltration.

Our hypothesis is that rebound thrombin generation occurs in ICU-patients after abrupt cessation of heparin treatment in terms of elevation of coagulation-markers and reduction fibrinolysis-markers; IV-weaning of heparin reduces this rebound…

Roles and responsibilities of parents and therapists in a Kindergarten Treatment Centre

The hypothesis is that all procedures look different per therapist and parent collaboration and all experiences are different. Nevertheless, there possibly will be similarities in experiences and wishes for the future.