271 results
The main objective of this part of the study (Work Package 1, WP1) which is part of a n European Union funded FP7 project entitled EUCLIDS is to develop, maintain and regulate the clinical network required to collect clinical data and patient…
To determine the genetic risk of susceptibility to, or severity of community-acquired pneumonia by comparing the interpersonal genetic variation of the host immune response of patients with community-acquired pneumonia to healthy controls and by…
1. To determine, in patients treated with TNF α blockers and living in the Q-fever endemic area, the prevalence of antibodies against C. burnetii and the prevalence of chronic Q fever.2. To assess other determinants in this group of patients which…
Primary: Evaluate new influenza A (H1N1) disease (pandemic influenza) incidence of vaccinated compared to unvaccinated individuals. Secondary: * Obtain data on immunogenicity of pandemic influenza vaccination:- Evaluation of the humoral immune…
To identify human genetic variants that influence susceptibility or resistance to HIV infection
Primary:- to determine the pharmacokinetics (PK) of parent drug and total radioactivity after administration of the studydrugSecondary:- to determine the absolute bioavailability of ITMN-8187 after oral administration- to investigate the safety and…
The principal goal of this study is to identify whether and how innate immune host factors predispose to the development of chronic Q-fever.
Confirm an association between RA and periodontitis and unravel pathogenic mechanisms underlying this association.
To investigate the diagnostic properties of Borrelia immunoblots from various manufacturers and compare the diagnostic properties of different bands, and to validate the diagnostic value of B. burgdorferi PCR on blood and urine.
To study the mechanisms by which T-cells can contribute to the defense against Aspergillus fumigatus.To study the role of the immune system and the role of Aspergillus antigens in the switch from a Th1 to a Th2 profile in patients with ABPA.
1. To establish whether serial exhaled breath analysis using eNose can detect invasive pulmonary aspergillosis in patients with prolonged chemotherapy induced neutropenia (neutrophil counts <0.5 x 10^9 for more than 7 days).2. To establish…
To compare: - the rate of local and systemic adverse events- height and duration of antibody presence using the plaque reduction neutralization test; - The number of yellow fever specific CD8+ T cells in peripheral blood mononuclear cells (PBMCs);…
To determine protective immunity against a heterologous P. falciparum sporozoites re-challenge after previous CPS immunization and challenge.
1. To describe the development of the nature of the immune system in early life in a profile of cytokines, chemokines and adipokines. 2. To evaluate less invasive methods like the use of saliva or less demanding methods like the use of dried bloods…
To investigate whether preventive use of the antibiotic ceftriaxone improves functional health outcomes in patients with stroke by preventing infection. This will be done in a large multi-centre randomized controlled trial. Within this trial we will…
To investigate what the ideal moment to vaccinate would be, early (after 2-6 months) or late (after 9-12 months) after cessation of rituximab. Secondly to study the immune-response to vaccination with influenza virus vaccine after treatment with…
To study if there is a role for prophylactic VZV vaccination prior to transplantation to boost the patients B- and T-cell repertoire and thereby reducing the incidence and morbidity associated with herpes zoster.
To examine the effect of BCG as a booster vaccine on salmonella typhi Vi polysaccharide vaccination
To evaluate neurologic- and cognitive disorders, neuroimaging and ophthalmological alterations in perinatally HIV-infected children in comparison to matched (with respect to age, sex, race, home environment and socio-economic status) healthy…
Has the supplementation of oligosaccharides in the first year of life an effect on the incidence of atopic diseases and infections from the 5th until the 7th year of life in healthy children