46 results
Primary Objective: (diagnostic)• Does MRI detect structural changes of haemophilic arthropathy in knees and ankles undetected by the Pettersson score and HJHS? (Research question 1 a & b)Secondary Objective(s): (prognostic)• Can MRI predict…
To characterise the number, phenotype and functionality of regulatory T cells and cytokines produced in the peripheral blood of children diagnosed with asthma.
The primary objective of this study is to assess the comparative safety and efficacy ofAztreonam Lysine for Inhalation (AZLI) and Tobramycin Nebuliser Solution (TNS) in adultand pediatric cystic fibrosis (CF) patients aged 6 years or older with…
To assess whether Th17 cells play a central role in COPD, CF and pneumonia pathogenesis
Aims: 1. To optimize the diagnosis of M. pneumoniae infections by discriminating between colonization and symptomatic infection using quantitative PCR. 2. To study the role of host factors (age, and bacterial and viral co-infection) on infection by…
This multicentre phase III study is designed to assess the efficacy and safety of recombinant versus E-Coli derived Aaparaginase from Medac, during treatment of children with newly diagnosed ALL according to the DCOG ALL-10 protocol.Futhermore: To…
To conduct a randomised trial to test the hypothesis that the experimental condition, i.e. the intervention*Gezin aan bod*, is superior to 'care-as-usual' in exerting a positive effect on a number of the risk factorsfor problematic…
1 To determine the phenotype and biological characteristics of mesenchymal stem cells derived from pediatric MDS patients as determined by flow cytometric analysis, cell culture and differentiation abilities analyzed by subtype of MDS compared to de…
Primary objective: to determine the effect of Mindful MirrorExposure in the treatment of eating disordered patients.
This project aims to examine the implementation and effectiveness of MST in The Netherlands.The aim of Implementation study is to determine the degree to which MST is implemented as intended at different sites in The Netherlands. Following questions…
The research strives for a large group of homogeneous AID patients, so that a powerful association study can be performed to detect genetic risk factors. These factors can be shared by several AIZ, or be specific is for a single AID. The aim of this…
Determining the prevalence of testicular microlithiasis in Down syndrome.
Primary objectives:(1) To describe the incidence of EV and HPeV infections in Dutch children(2) To determine the major symptoms of EV/HPeV infections in children(3) To evaluate the epidemiology and symptoms of the different subtypes of EV and HPeV(4…
Objective of the study: The main objective of this study is to investigate the influence of different genetic mechanisms (risk genes, CNVs and gene expression profiles) in ASD and to study the relation between the genetic heterogeneity and specific…
This hypothesis will be challenged in five objectives:1. To check the factorial validity of two cognitive styles - weak central coherence; poor cognitive shifting - in patients with MR and ASS.2. To assess the specificity of the association between…
The objectives of this study are:1) assess the differences in pain sensitivity between children with and without chronic pain2) collecting normative data for pain sensitivity in children aged 8-123) investigate the relationship between parental…
The object of this study is to determine the effects of an eccentric muscle training for the supraspinatus muscle compared to the effects of a traditional rehabilitation program including strengthening exercises for the rotator-cuff and the scapular…
First, to develop a diagnostic method for non-infectious uveitis in childhood. Second, to analyze iris and ciliary body tissues of children with uveitis on the presents of inflammatory infiltrate. The results of this study will contribute in the…
The objective of this research is to develop a method which can identify among all consanguineous couples the ones which are at high risk.
In this pilot study the effects of exercise on muscle energetics in the proximal muscle groups of the legs with patients with Juvenile Dermatomyositis will be cross-sectional studied. This will be done with an exercise test using a recumbent bicycle…