36 results
More sustained knowledge of the intracellular processes regarding S1P in lymphocytes could be beneficial in modulating specific immune responses in transplantation medicine, autoimmune diseases and sepsis. Therefore, in this study, we will…
The purpose of this study is to investigate how quickly and to what extent PF-06650833 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). PF-06650833 is not registered as a drug, but…
Determine if there are immunological or patient characteristics in UC patients that predict the endoscopic response on Vedolizumab treatment.
With this pilot feasibility study, the feasibility of and satisfaction with an eHealth and serious gaming training based on psychological expectancy mechanisms are evaluated.
ln this study effect of 3 novel compounds on the development of psoriasis in the humanized mouse model isinvestigated. The efficacy is compared to one registered drug, namely Remicade(R).
1). Evaluate the expression of the genes encoding the enzymes that modify histones and DNA during monocyte differentiation in MS.2). Consequences of monocyte dysfunction for migration and cytokine/chemokine production.
The primary objective of this study is to identify parameters that predict bleeding risk in children with chronic ITP. Secondary objectives are: 1) To investigate whether children with long lasting chronic ITP differ from children with newly…
Characterization and extending the use of the humanized mouse model for psoriasis for pre-clinical testing of new drug.Limited screening of compound B for a pharmaceutical company.Therefore, depending on the success rate of transplantation and…
In previous projects a number of compounds were tested that had a positive effect in the transplant model of psoriasis. However, it proved difficult to prepare formulations that were stable enough to use in clinical studies. A new compound (CD07813…
ln this study the effect of 2 novel compounds on the development of psoriasis in the humanized mouse model is investigated. The efficacy is compared to one registered drug, namely Stelera.
The aim of the project is to test BS6.890C in the prophylactic transplant model of psoriasis.
The specific aim of the project is to determine the efficacy of Spherical Nucleic Acids (SNAs) on psoriasis skin biopsy gene expression in vitro.
The specific aim of the project is to determine the efficacy of Spherical Nucleic Acids (SNAs), delivered in a gel, on psoriasis skin biopsy gene expression in vitro.
Our aims are to identify the clusters of impairments in cognition, behavior, quality of life, and fatigue in children after anti-NMDAR encephalitis, to identify risk factors affecting functional outcome and to assess the progression or remission…
The main objective of the study is to see if the test compounds can prevent the development of a psoriatic lesion induced in non-lesional skin from psoriasis patients which has been transplanted onto immune-deficient mice.
To objectively investigate retinal function deterioration due to the inflammatory process by ERG. To investigate if risk factors for loss of ERG activity in uveitis herald more aggressive immunomodulation treatment to prevent visual loss.
The primary study objective is to examine functionality and usability of a newly developed eHealth and serious gaming intervention, to ensure that the intervention is user-friendly and fits the needs of potential users. Based on these functionality…
In this study the efficacy of a novel monoclonal antibody on the development of psoriasis in the humanized mouse model will be investigated.This experimental compound will be compared with 2 registered drugs, i.e. Humira en Stelara.
To see if the new drug can prevent development of psoriatic changes in the transplant model of psoriasis
To see if the new drug can prevent development of psoriatic changes in the transplant model of psoriasis