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The effect of Alphabodies® against human lnterleukin lL23 in the transplant model of psoriasis, in which a psoriatic lesion is induced in non-lesional skin transplanted onto immune-deficient (BNX) mice by injecting super-antigen activated peripheral blood cells intradermally into the transplant.

Are Alphabodies against IL23 effecive in the transplant model of psoriasis

The effect of Spherical Nucleic Acids on target gene expression in full thickness biopsies taken from lesional skin of volunteers with psoriasis vulgaris.

The specific aim of the project is to determine the efficacy of Spherical Nucleic Acids (SNAs) on psoriasis skin biopsy gene expression in vitro.

Development of a psychological expectancy training - phase 3: pilot feasibility testing

With this pilot feasibility study, the feasibility of and satisfaction with an eHealth and serious gaming training based on psychological expectancy mechanisms are evaluated.

A phase 1, open-label, 2-period, fixed sequence, study to investigate the absorption, metabolism and excretion of 14C-PF-06650833 and to assess the absolute bioavailability and fraction absorbed of PF-06650833 in healthy male subjects using a 14C-microdose approach.

The purpose of this study is to investigate how quickly and to what extent PF-06650833 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). PF-06650833 is not registered as a drug, but…

Immunological characteristics in UC patients that predict response on Vedolizumab

Determine if there are immunological or patient characteristics in UC patients that predict the endoscopic response on Vedolizumab treatment.

In vitro investigation into the potential regulating role of sphingolipids in lymphocyte proliferation.

More sustained knowledge of the intracellular processes regarding S1P in lymphocytes could be beneficial in modulating specific immune responses in transplantation medicine, autoimmune diseases and sepsis. Therefore, in this study, we will…

The effect of BS6.890C in the prophylactic transplant model of
psoriasis in which a psoriatic lesion is induced in non-lesional skin
transplanted onto immune-deficient (BNX) mice by injecting superantigen
activated peripheral blood cells intra-dermally into the
transplant.

The aim of the project is to test BS6.890C in the prophylactic transplant model of psoriasis.

Efficacy of a three novel compounds in a humanized mouse model of psoriasis

ln this study effect of 3 novel compounds on the development of psoriasis in the humanized mouse model isinvestigated. The efficacy is compared to one registered drug, namely Remicade(R).

Monocyte dysfunction in Multiple Sclerosis (MS)

1). Evaluate the expression of the genes encoding the enzymes that modify histones and DNA during monocyte differentiation in MS.2). Consequences of monocyte dysfunction for migration and cytokine/chemokine production.

Chronic disease in Immune Thrombocytopenia of Childhood

The primary objective of this study is to identify parameters that predict bleeding risk in children with chronic ITP. Secondary objectives are: 1) To investigate whether children with long lasting chronic ITP differ from children with newly…

Characterization and extending the use of the humanized mouse model for psoriasis for pre-clinical testing of new drug.

Characterization and extending the use of the humanized mouse model for psoriasis for pre-clinical testing of new drug.Limited screening of compound B for a pharmaceutical company.Therefore, depending on the success rate of transplantation and…

The effect of CD07813 in the transplant model of psoriasis; in which a psoriatic lesion is induced in non-lesional skin transplanted onto immune-deficient (BNX) mice by injecting activated peripheral blood cells intra-dermally into the transplant. RD/10/15700

In previous projects a number of compounds were tested that had a positive effect in the transplant model of psoriasis. However, it proved difficult to prepare formulations that were stable enough to use in clinical studies. A new compound (CD07813…

Efficacy of two novel compounds in a humanized mouse model of psoriasis

ln this study the effect of 2 novel compounds on the development of psoriasis in the humanized mouse model is investigated. The efficacy is compared to one registered drug, namely Stelera.

The effect of HPP-A in the transplant model of psoriasis; in which a psoriatic lesion is induced in non-lesional skin transplanted onto immune-deficient (BNX) mice by injecting super-antigen activated peripheral blood cells intra-dermally into the transplant

Client wishes to see if HPP-A is active in the transplant model of psoriasis

The effect of CMPX-2023 in the transplant model of psoriasis; in which a psoriatic lesion is induced in non-lesional skin transplanted onto immune-deficient (BNX) mice by injecting super-antigen activated peripheral blood cells intra-dermally into the transplant.

Is CMPX-2030 effective in the transplant model of psoriasis

Efficacy of a novel experimental antibody in a humanized mouse model of psoriasis

In this study the efficacy of a novel monoclonal antibody on the development of psoriasis in the humanized mouse model will be investigated.This experimental compound will be compared with 2 registered drugs, i.e. Humira en Stelara.

The effect of SF396 in the transplant model of psoriasis

To see if the new drug can prevent development of psoriatic changes in the transplant model of psoriasis

Efficacy of a proprietary compound B in a humanized mouse model of psoriasis

Test efficacy of compound B in humanized mouse model of psoriasis.

Efficacy of MT204 in a humanized mouse model of psoriasis - Module 2 -

In this study the dose reponse of compound MT204 on the development of psoriasis in the humanized mouse model is investigated. The efficacy of MT204 is compared to two registered drugs, namely Ustekinumab and Daclizumab.

The effect of an antibody (Ab) against human IL-6 in the transplant model of psoriasis.

To see if the new drug can prevent development of psoriatic changes in the transplant model of psoriasis