30 results
Sample collection for in vitro research
The objective of this study is to further unravel the complexity of human milk and its variations over lactation stages and between individuals.
Primary objectives: - To examine how environmental exposures influence the prevalence, 5-year incidence and progression of cardiometabolic and chronic respiratory disease in the general population. - To determine the mediation effect of lifestyle…
The primary objective of this cohort study is to determine the prevalence of simple and progressed NAFLD in subjects at risk followed by the general practitioner The secondary objectives are:1. To study the factors linked to the development of…
The aim of this research proposal is to examine the effect of different ISIs on mTc-MEPs.Primary research question: What is the effect of different interstimulus intervals (ISIs) on mTc-MEP thresholds, peak-to-peak amplitudes, and area under the…
The aim of this project is to evaluate the clinical value of biomarkers in adult patients with pulmonary hypertension, in particular:1) To quantify biomarkers of neurohormonal activity as NTproBNP, endotheline-1 and of immunological activity as CRP…
To examine the prevalence, risk factors and mechanisms of impaired health outcomes (short- and long-term medical and psychosocial effects and late effects) over time among a population-based sample of AYA cancer patients.Primary Objective: - To…
The primary objective of this study is to build a predictive model in which we can identify which (pheno) type of ALS patients has the most benefit from NIV in improving or maintaining quality of life.
The objective of the study is to establish a data infrastructure to investigate the degree in which current and previous generations of young-old are characterised by healthy and successful ageing.
1) To collect information on patient characteristics, short- and long-term clinical and patient-reported outcomes; and 2) to create an infrastructure for efficient, fast, and pragmatic randomized evaluation of new interventions.
The purpose of this study is to evaluate the feasibility and efficiency of transducing freshly obtained CD34+ HSC from either mobilized peripheral blood or bone marrow of healthy donors using lentiviral SIN vectors encoding codon-optimized human…
The main study objectives include to:a. Use clinical and biological data to estimate the mean rates of change and the variability around the mean of clinical, digital, imaging, biological and genetic outcomes in study participants…
First, to establish the yield of the currently propagated pancreatic cyst surveillance program, and second, to identify possible alternative surveillance strategies, which might be more (cost) effective.
To evaluate the feasibility of remote eCTG monitoring in complicated pregnancies between 32-37 weeks in a Home@Hospital setting. Secondary objectives are to evaluate automated interpretation of remote eCTG monitoring and to assess perinatal and…
The primary objective of the current pilot study will be to assess the feasibility of participant selection methods to identify individuals with cam morphology free of hip OA.Secondary objectives includea) the evaluation of the willingness of…
The prognostic accuracy of combining these four criteria to predict the later development of personality disorders (with/without psychosocial breakdown) is investigated in a longitudinal study. From this, a selection of items with the strongest…
1. To identify the perceived barriers and facilitators for initiating and maintaining a healthy lifestyle in people with both DM2 and a low SEP. 2. To co-create a digital, personalised CBT lifestyle tool together with end users (people with DM2) to…
The study will help us to determine 1. the necessary type of (combined) examinations and 2. the sample size that is essential to evaluate (future) genetic therapy in Usher syndrome type 2 and USH2A associated nsRP.
The aim of this proof-of-concept study is to analyze the use of heart rate based variables using the Apple Watch:A) To predict Acute Chest Syndrome in patients hospitalized patients for painful crises;B) To predict painful crises in ambulant…
Given the above mentioned gaps in knowledge, the aim of this project is to1) Describe the midterm and long-term outcomes of (primary and revision) total hip, total knee and shoulder replacement surgery in terms of health status as a whole,…