20 results
1. We will recruit 30 probands who meet DSM-IV inclusion criteria for a primary psychotic disorder or mood disorder with psychotic features: schizophrenia, schizoaffective disorder, delusional disorder, bipolar I disorder, psychotic depression, post…
To explore the clinical role of infection and inflammation in lumbar and cervical radiculopathy.
We aim to describe and identify distinct daily glucose patters (DGP) in the general population that are related to increased risk of diabetes and diabetes related micro- and macro-vascular complications using the flash sensor technology through the…
Primary Objective:To characterize a cohort of STXBP1-encephalopathy patients in a standardized, integrative manner, including in-depth clinical profile characterization and EEG recordings. Moreover, for a subgroup of patients, iPSC-derived induced…
The aim of this study is to combine acoustic characteristics from spontaneous speech and results from tests at different linguistic levels e.g. the Diagnostic Instrument for Mild Aphasia (DIMA), to determine which aspects in speech are most…
Brain tumors: Characterize and quantify changes in immune parameters during disease in patients with a CNS malignancyAML: Characterize and quantify changes in immune parameters and immunotherapeutic targets during disease in pediatric patients with…
In-vivo validation of protein makers in minimal invasive skin biopsies from persons with blunt injuries in different time periods.
Primary objective:To identify common mutations or other genetic alterations and their potential as therapeutic targets in granulosa cell tumours, by studying human granulosa cell tumour specimens and establishing 3D organoid cell cultures derived…
In this clinical project we aim to fill in gaps in our knowledge on muscle fiber contractility, auto-immunity and myositis: 1) How responsive is human muscle fiber contractility following standard of care immunosuppressive treatment? 2) Is the…
Objective 1: The LifeMeds cohort aims to longitudinally identify characteristics of individuals with multimorbidity (at least two of the following chronic diseases: CVD, CRDs,T2DM and/or cancer), including lifestyle behavior and its determinants. 1a…
Primary objective: To assess the feasibility of donor screening, collection, production and storage of sufficient CB-RBC products to potentially meet the transfusion need in extremely preterm neonates.
The overall aim of the Ageinglines cohort study is to better understand the biological ageing process and its association with the onset (pre)frailty and well-being in later life and to identify targets for delaying the biological ageing process…
The REPLACE study aims to determine whether not changing the catheter (catheter retained) for catheter-associated urinary tract infections (CAUTI)affects the recurrence-risk of CAUTI.
This is a pilot study for investigating the cause of recurring cerebral thrombo-embolic events in a patient after (branched) TEVAR surgery. The main aim of this logistical pilot is to develop a workflow for investigating blood flow patterns in such…
Primary objective is to investigate if the sEMG signal derived from the SERA device has an association with weaning failure, defined as an unsuccessful SBT, or extubation failure, defined as the need for re-intubation for respiratory reasons within…
The general objective is to validate a new non-invasive retinal imaging tool that allows the identification of relevant biomarkers in the retina in degenerative diseases of the brain and the eye by scattering and absorption properties.
Optimization of OE-MRI protocols and workflows to prepare for hypoxia mapping and quantification on an MR-linac
The objective is to initiate a hiPSC-resource from 10 genotyped participants of the Doetinchem Cohort Study, with a characterized life course history of up to 35 years during their adult life, with the intent to deploy mechanistic and causality…
Primary RQ: 1) Is time spent in daylight associated with better mood in recently remitted depression patients? Secondary RQ*s: 2) Is the association dependent on age, sex, circadian rhythms and chronotype? 3) Is the association dependent on timing…
We have preliminary data from blood collected in other studies that indeed measuring blood microbiomes is more informative as sampling the corresponding faeces samples and we have built a bio-informatical pipeline that apparently allows its analysis…