50 results
In this study the efficacy of a novel monoclonal antibody on the development of psoriasis in the humanized mouse model will be investigated.This experimental compound will be compared with 2 registered drugs, i.e. Humira en Stelara.
To see if the new drug can prevent development of psoriatic changes in the transplant model of psoriasis
To see if the new drug can prevent development of psoriatic changes in the transplant model of psoriasis
This study concerns a research that is aimed to investigate the prevalence of the metabolic syndrome in a group of patients known with ANCA-associated vaculitis. Hereby we will compare the presence of the metabolic syndrome between an ANCA-…
The primary purpose is validation of the dutch version of a brief health-related quality of life (HRQOL) tool in children with systemic lupus erythematosus (SLE). This tool is called *Simple Measure of Impact of Lupus Erythematosus in Youngsters© (…
Test efficacy of compound B in humanized mouse model of psoriasis.
In this study the dose reponse of compound MT204 on the development of psoriasis in the humanized mouse model is investigated. The efficacy of MT204 is compared to two registered drugs, namely Ustekinumab and Daclizumab.
Test efficacy of compounds D+E in humanized mouse model of psoriasis.
Is topical application of compound Z effective in reducing the development of psoriasis, induced in this humanized mouse model?
Are Alphabodies against IL23 effecive in the transplant model of psoriasis
objective
To collect and store a serum sample of each patient that is referred to the Leiden University Medical Centre for evaluation of neuropsychiatric symptoms in SLE.
Client wishes to see if HPP-A is active in the transplant model of psoriasis
To evaluate the reproducibility of the SvdH score (BE and JSN of one hand) of radiographs taken with a mould compared to conventionally acquired images.
Is CMPX-2030 effective in the transplant model of psoriasis
The main aim of the proposed study is to 1) assess the habitual consumption of raw cow*s milk among a large population of adult dairy farmers; 2) assess the association between raw cow*s milk consumption and inflammation-related, auto-immune and…
The main objective is to investigate the association between walking fatigability during the 6 minute walking test (6MWT) and walking economy in pwMS who are able to walk independently. Secondary objectives are to investigate the role of I. walking…
To study patients with clinically suspect arthralgia in order to 1) develop diagnostic/prognostic markers (a. markers of systemic and b. local inflammation as well as c. autoantibodies) for the development of RA 2) to improve the mechanistic…
The primary objective of this study is to assess the prevalence of Temporomandibular Joint Disorders in (1) rheumatoid arthritis (RA) patients, (2) individuals at increased risk of RA, and (3) a control group without autoimmune diseases and to…
The purpose of the study is to investigate how quickly and to what extent PF 04965842 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). A small part of the PF 04965842 to be…