15 results
The primary objectives of this study are:* To evaluate tracer kinetic models for the purpose of quantifying specific binding of 18F-AV-1451 in cross sectional and longitudinal applications; and* To evaluate simplified methods for quantification of…
Are changes in cognitive functioning related to structural changes in the brain in patients with type 1 diabetes mellitus. How are these changes related to diabetic complications like duration of chronic hypoglycaemia, disease duration and presence…
To assess the potential of a short neuropsychological test measuring attentional variability and vigilance preoperatively in predicting postoperative delirium among elderly non-dementia patients undergoing elective surgery.
- to determine possible differences in the results of the ABILHAND kids questionnaire between parent, occupational therapist and rehabilitation doctor- variance of the results in time
To evaluate the course of concentrations of oxidative stress parameters and neuro-biomarkers in cord blood, serum and urine of full-term asphyxiated neonates. Furthermore, to investigate whether these concentrations are correlated to hypoxic…
Hereto, the project wants to meet the following goals:1. To produce an EEG instrument for continuous brain monitoring, the NeoGuard, enabling automated detection of neonatal seizures and abnormalities in the EEG background pattern. The neonatal…
To evaluate the prognostic value of the EEG, including quantitative EEG features, TMS and SSEP after out-of-hospital cardiac arrest.
Goals• Increase the knowledge of the Pgp in the pathophysiology of Alzheimer's disease. • Designing an in vivo method, by positron emssion tomography, for measuring Pgp function and Aβ concentration to possibly determine the risk of converting…
To assess if the studied TCD variables of cerebral autoregulation and hemodynamics are abnormal during preeclampsia. And if so, to determine if these changes are large enough to have potential value to determine a threatening cerebral dysfunction in…
The main objective of the study is to acquire more insight in memory for emotional information in patients with Alzheimer*s Disease, compared to healthy elderly people. A second objective is to explore the effect of emotional content on working…
Primary Objective: to determine the strength of the dynamic autoregulation of patients after cardiac arrest during the post cardiac arrest syndrome. Secondary Objectives:to observe the natural course of the autoregulation during the first year after…
To 1) clinically validate the novel PET-tracer [18F]AV1451 for tau pathology as a diagnostic and prognostic marker in tauopathies, 2) to examine the (change in) (regional) binding of [18F]AV1451 across tauopathies, and the relationships between (…
To determine the potential impact of ball heading in football on brain integrity as assessed by blood biomarkers for neural damage in a real-world setting.
This protocol is a follow-up of a previously submitted protocol (Evaluation of [18F]AV-1451 kinetic modelling in patients with Alzheimer*s Disease and healthy controls, protocol nr. 2014.519), in which the optimal (simplified) kinetic model for [18F…