25 results
The primary objectives of this study are:* To evaluate tracer kinetic models for the purpose of quantifying specific binding of 18F-AV-1451 in cross sectional and longitudinal applications; and* To evaluate simplified methods for quantification of…
Are changes in cognitive functioning related to structural changes in the brain in patients with type 1 diabetes mellitus. How are these changes related to diabetic complications like duration of chronic hypoglycaemia, disease duration and presence…
To assess the potential of a short neuropsychological test measuring attentional variability and vigilance preoperatively in predicting postoperative delirium among elderly non-dementia patients undergoing elective surgery.
- to determine possible differences in the results of the ABILHAND kids questionnaire between parent, occupational therapist and rehabilitation doctor- variance of the results in time
To evaluate the course of concentrations of oxidative stress parameters and neuro-biomarkers in cord blood, serum and urine of full-term asphyxiated neonates. Furthermore, to investigate whether these concentrations are correlated to hypoxic…
Hereto, the project wants to meet the following goals:1. To produce an EEG instrument for continuous brain monitoring, the NeoGuard, enabling automated detection of neonatal seizures and abnormalities in the EEG background pattern. The neonatal…
Primary Objective: 1) To charaterize microbleeds and microinfarcts at 7T, and compare their prevalence in people with and without diabetes, with or without cognitive impairmentSecondary Objective(s): 2) To assess the relevance of the lesions in the…
Primary Objective: 1) To compare the prevalence en number of microbleeds at 7T between older people with and without DM2, and to relate the lesions to cognitive performanceSecondary Objective(s): 1) To characterize cerebral microinfarcts at 7T and…
To evaluate the prognostic value of the EEG, including quantitative EEG features, TMS and SSEP after out-of-hospital cardiac arrest.
Goals• Increase the knowledge of the Pgp in the pathophysiology of Alzheimer's disease. • Designing an in vivo method, by positron emssion tomography, for measuring Pgp function and Aβ concentration to possibly determine the risk of converting…
To assess if the studied TCD variables of cerebral autoregulation and hemodynamics are abnormal during preeclampsia. And if so, to determine if these changes are large enough to have potential value to determine a threatening cerebral dysfunction in…
The main objective of the study is to acquire more insight in memory for emotional information in patients with Alzheimer*s Disease, compared to healthy elderly people. A second objective is to explore the effect of emotional content on working…
Primary objective is to assess in vivo neuroinflammation quantitatively in patients with sepsis. Secondary objective is to study whether differences in in vivo neuroinflammation are related to long term cognitive outcomes.
Primary Objective: to determine the strength of the dynamic autoregulation of patients after cardiac arrest during the post cardiac arrest syndrome. Secondary Objectives:to observe the natural course of the autoregulation during the first year after…
Primary objective is to quantitatively assess differences in in vivo neuroinflammation in patients before and after coronary artery bypass grafting (CABG) surgery. Secondary objective is to study whether diffferences in in vivo neuroinflammation are…
1. To estimate the additional value of early MRI monitoring for the prediction of neurological outcome of comatose patients after cardiac arrest. 2. To gain insight in the pathophysiology of PAE by functional MRI measures and by associating MRI…
To 1) clinically validate the novel PET-tracer [18F]AV1451 for tau pathology as a diagnostic and prognostic marker in tauopathies, 2) to examine the (change in) (regional) binding of [18F]AV1451 across tauopathies, and the relationships between (…
Using single-cell transcriptomic and epigenetic profiles of (immune) cells in liquor to investigate which biological and cellular processes are involved in (accelerated) brain aging and cognitive decline after systemic inflammation.
The primary goal of NEwTON is to study the link between repetitive head injury and neurodegeneration, leading to cognitive, psychiatric and behavioral symptoms as found in CTE. We will collect a prospective cohort of patients at high risk of CTE,…