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Pilot study of DEHP and BPA exposure during and after delivery, in mother and child

We seek to elucidate the perinatal exposures to DEHP and BPA with the intention of providing evidence for policy makers and manufacturers. It is our hope that less toxic products will be used in health care and in the general population in the…

INDEX:Costs and effects of induction of labour versus expectant management in women with impending post-term pregnancies: the 41 week-42 week dilemma

First ObjectiveIn this study we compare a policy of labour induction at 41 weeks with a policy of expectant management until 42 weeks, with an outpatient check for CTG monitoring and ultrasound measurement in the 42nd week, with respect to the…

Intrauterine resuscitation during term labor by maternal hyper oxygenation: a pilot study.

To investigate the effect of maternal hyperoxygenation with 100% in the second stage of labor and in the presence of abnormal fetal heart rate (FHR) patterns on fetal condition, instrumental delivery rate and free radical production. In case a…

Anorectal function and the effect of childbirth in patients with M Crohn

Disease activity, perianal involvement and lesion localisation are important influential parameters making sure no pregnancy is exactly alike and mode of delivery needs to be considered on an individual patient level.A complete anorectal function…

Development of brief intervention for prenatal alcohol use

The goal of this study is to develop and test two tailored intervention programs to stimulate pregnant women to stop drinking alcohol. These intervention programs are a health counseling and a computer tailored intervention. The efficacy of the…

Fertility follow-up of women who visited the outpatient fertility ward for information on fertility preservation before starting gonadotoxic treatment

Fertility follow-up of the women who visited our out patient ward for information on fertility preservation before starting gonadotoxic treatment

Patients' view on the prevention of preterm birth (Preventing preterm birth in women with a previous preterm birth: identification of obstacles to change)

The aim of this study is to identify factors that can hamper of facilitate the implementation and to use this knowledge to develop an effective implementation strategy.

Pessaries in mulitple pregnancy as a prevention of preterm birth

To investigate the hypothesis that in women with a multiple pregnancy prophylactic use of a pessary will be effective in the prevention of preterm delivery and the neonatal mortality and morbidity resulting from preterm delivery. To assess in women…

The prevalence of postpartum posttraumatic stress symptoms, depression, anxiety and the need of control in women delivered in The Netherlands

To assess the prevalence of postpartum posttraumatic stress symptoms, depression, anxiety and the need of control in women delivered in The netherlands.

Prediction of early onset intra uterine growth retardation using morphologic and endocrine placental parameters.

The aim of this project is to investigate whether a first trimester model of 3D placental volume, 3D power Doppler measurement of the placental vascularization and/ or serum levels of PAPP-A, PlGF, PP-13, PAI, Ang-2, sFlt and SEng can predict early…

SIMPLE III; a randomised controlled non-inferiority trial: best timing for a caesarean section in non-progressing labour;

To compare the currently used Friedman partogram (FP) to the newly developed SIMPLE partogram (SP), based on the normogram of the consortium on Safe Labor, for the diagnosis and treatment of non-progressing labour.

A lifestyle intervention to reduce gestational weight gain and smoking in pregnant women to prevent perinatal morbidity

The overall aim is to study the effects of a lifestyle intervention for young women who are pregnant <= 12 weeks of gestational age and have a high risk on perinatal morbidity because of prepregnancy overweight or obesity and, if applicable,…

PREGCOVAC-19: the follow up of pregnant women who received COVID-19 vaccination in the Dutch national vaccination program

We have defined the following milestones/deliverables for this project:1. Evaluation of IgG antibody response in pregnant women after participation in the Dutch national COVID-19 vaccination program.2. Evaluation of the relation between gestational…

BMI dependent regulation of macrophages and monocytes in pregnancy

Primary Objective: analyse the effect of maternal BMI on levels of macrophage cell and monocyte subsets in decidual tissue and maternal blood. Secondary Objective: analyse differences in the effect of maternal blood stimulation with conditioned…

Living to the full during pregnancy: Increasing resilience during pregnancy to prevent peripartum depression

Aims of the study:1. To evaluate the effect of a guided self-help resilience training for pregnant women with depressive symptomatology on:a) primary outcomes: maternal depressive symptoms and resilience; andb) secondary outcomes including maternal…

The effectiveness of Cerclage for the reduction of extreme preterm birth and
perinatal mortality in Twin pregnancies with a short cervix.

To assess the effectiveness of a cerclage in women with a twin pregnancy with a midpregnancy short cervix compared to standard treatment (no cerclage) in the prevention of extreme preterm birth (PTB) < 28 weeks of GA.

Generation R Next intervention study

For this reason, we will conduct an intervention study aimed at promoting the health of (future) parents. The concrete goal of this intervention is to improve the health of (future) parents by optimizing lifestyle in the preconception period and…

Personalized hemodynamically guided antihypertensive treatment in pregnant women with mild to moderate hypertension: a randomized controlled trial

To evaluate whether personalized antihypertensive treatment of mild to moderate gestational hypertension based on maternal hemodynamic profile leads to effective treatment of hypertension with better maternal and neonatal outcome compared to no…

Pregnancy Outcomes: Effects of Metformin Study (POEM Study), a long term randomized controlled study in gestational diabetes mellitus

This study has been transitioned to CTIS with ID 2024-519386-21-00 check the CTIS register for the current data. The central aim of the POEM Study: to investigate whether the early start of metformin on top of standard care may improve the treatment…

TOwards Prepared mums (TOP-mums), for a healthy start: A lifestyle intervention to reduce overweight and smoking in women with a pregnancy wish to prevent perinatal morbidity

The overall objective of the study is to investigate a lifestyle intervention for women with a pregnancy wish or pregnant women in their first trimester, and a high risk on perinatal morbidity because of (prepregnancy) overweight or obesity. With an…