52 results
Sample collection for in vitro research
To investigate whether high perceived stress is associated with inflammatory reprogramming of innate immune cells and their bone marrow progenitors, and with increased arterial wall inflammation, in subjects with an increased CVD risk.
In this study, we therefore aim to investigate how trained immunity is systemically regulated in kidney transplant patients and how the degree of trained immunity affects graft survival in patients. A better understanding of these processes…
Main objective: 1. Determine the feasibility, in terms of system fidelity and acceptability, of remote, image-based monitoring in cardiac surgery patients on a general ward. Secondary objectives: 1. The validity of remote, image-based heart- and…
The primary objective is to investigate if the stress-induced dynamics across stress systems are impaired in patients with CT-related depression compared to non-CT-related depression and healthy controls. The secondary objective is to examine how…
To evaluate whether we can determine the health status of the joint by measuring biomarker levels using a newly developed assay by the University of Twente based on the multiplex measurement of a panel of relevant biomarkers using Surface Plasmon…
The primary objective is to assess diagnostic accuracy of MRDTI/BTI for first and recurrent CVT in patients referred for MRI/MRV in the setting of routine clinical setting. The secondary objectives are to optimize MRDTI/BTI sequences for imaging…
The primary objective of this cohort study is to determine the prevalence of simple and progressed NAFLD in subjects at risk followed by the general practitioner The secondary objectives are:1. To study the factors linked to the development of…
The primary objective is to explore whether central sensitization and/or abnormal CPM responses are present in (a subgroup of) patients who will receive shoulder arthroplasty for osteoarthritis, and whether shoulder arthroplasty produces change in…
The aim of this research proposal is to examine the effect of different ISIs on mTc-MEPs.Primary research question: What is the effect of different interstimulus intervals (ISIs) on mTc-MEP thresholds, peak-to-peak amplitudes, and area under the…
Development of new imaging techniques for MR-guided motion management in the presence of respiratory motion
1A) To implement a screening-protocol for HIV related co-morbidities and their risk factors, based on multidisciplinary expert consultation, in a large HIV outpatient clinic and among an HIV-uninfected control group.1B) To assess the prevalence and…
The primary objective of this study is to establish molecular profiles in lower rectal biopsies as close to the internal fistula orifice tissue and fistula scrapings based on single cell RNA sequencing, cellular protein expression by CyTOF and…
1. To study the possibility to detect gynaecological malignancies and endometriosis in vaginal self-swabs, Pap smears and blood of women with gynaecological cancer or endometriosis, using MeD-seq and MeD-scan assays, in order to develop…
The aim of this project is to evaluate the clinical value of biomarkers in adult patients with pulmonary hypertension, in particular:1) To quantify biomarkers of neurohormonal activity as NTproBNP, endotheline-1 and of immunological activity as CRP…
The aim of this current proposal is to compare test methods for determining TFS performance, to establish detection thresholds for both CI users and normal hearing subjects and to produce normative data for the computer model and machine learning…
Primary objective: to register and investigate Dutch patients suspect for an inherited platelet function disorder, to assess clinical presentation, bleeding score, treatment, burden of disease and quality of life. Secondary objectives: to…
Primary objective Primary objective is to create a prediction model based on early clinical screening of motor, cognitive, and emotional disturbances to predict restrictions in participation at one year after cardiac arrest in patients that have…
The primary objective of this study is to build a predictive model in which we can identify which (pheno) type of ALS patients has the most benefit from NIV in improving or maintaining quality of life.
The objective of the study is to establish a data infrastructure to investigate the degree in which current and previous generations of young-old are characterised by healthy and successful ageing.